heme Flashcards Preview

LAST MINUTE! > heme > Flashcards

Flashcards in heme Deck (44):
1

PMN chemotaxis

IL-8
LTB4
C5a
kallikrein
PAF

2

eosinophil products

histaminASES
MBP

3

Sphereocytes

ANY type of hemolytic anemia
- hereditary sphereocytosis
- AHA (cold or warm)
Also burns and old samples

4

basophilic stippling is:

rRNA - lead prevents its degradation

5

Overlapping metal Rxs

Dimercaprol and succimer
for lead, mercury, gold, arsenic

6

causes of sideroblastic anemia

--| ala synthase

XR, lead, B6 deficiency (or INH), alcohol, copper deifciency

7

kid with failure to thrive, developmental delays and B12/folate resistant megaloblastic anemia

Orotic aciduria
AR, no UMP synthase .: rx = UMP

NO hyperammonemia (OTC deficiency)

8

ACD

increased hepcidin ---| ferroportin (BL enterocytes + macrophages)

9

aplastic anemia causes

*NO HSM!

drugs - benzene, chloramphenicol, chemo
radiation
viral - B19, EBV, HIV, HCV
Fanconi ANEMIA
idiopathic (immune or 1' SC defect); may follow acute hepatitis

10

back pain with hemoglobinuria

G6PD
(Hb is nephrotoxic)

11

hemolytic anemia in the newborn

pyruvate kinase deficiency

12

PNH triad and labs and rx

Triad:
- coombs -ve H.A.
- pancytopenia (high up SC defect, can get AML)
- venous thrombosis

Lab = no CD55/59 on RBC flow

Rx = eculizumab (C5 inhibitor)

13

transferrin levels in hemochromatosis

DECREASED (to try to lower it)

14

batteries and ammunition exposure

lead poisoning

15

AIP enzyme and s/s

porphobilinogen deaminase
5Ps (pain, port-wine, polyneuropathy, psychological, ppt drugs = 450 inducers, alcohol, starvation)

16

PCT enzyme

uroprophyrinogen decarboxylase

17

immune thrombocytopenia:
Abs
Ppt factor
rx

IgG Abs to GpIIb/IIIa
ppt by viral infection, SLE, HIV, HBC
Rx = steroid and IVIG for spleen to eat those

18

TTP MOA and pentad:

MOA: ADAMTS problem; can't chop up vWF so big multipliers super-activate platelets and you get clots

pentad: thrombocytopenia, microangiopathic H.A., neurologial, renal, fever

19

prothrombin gene mutation

3'UTR point mutation causing INCREASED prothrombin production

20

cyroppt

fibrinogen
vWF
VIII
XIII
Fibronectin

21

high WBCs, low LAP

CML

22

lymphoma with strong EBV associations

Hogkins (owl eyes, CD15 and 30)
non-hodgkins - endemic burkits t(8;14)

23

Functions of the genes in cancer translocations:

- 8;14

- 14;18

- 11;14

- 9;22

- 15;17

- 8;14: 8 = c-myc = TC activator = burkitts

- 14;18: 18 = bcl-2 = blocks apoptosis = follicular

- 11;14: 11 = cyclin D1 = cell cycle regulator = mantle cell

- 9;22: 22 = abl = tyrosine kinase (cyto + nuc) = CML

- 15;17: 15 = RAR = myelocyte differentiation = PAML

24

microsomal monooxygenase =

p450

25

hematology drug causeing neutropenia presenting as fever and mouth ulcers

Ticlopidine (ADP-R blocker)

use only if allergic to asprin + clopidogrel

26

Features of anaplastic cells

loss of polarity, nuclear polymorphism, irregular mitoses, high N:C, giant multinucleated tumour cells

27

Rb-P means:

inactivated

cell can progress thru cell cycle (G1 to S)

28

AT-III deficiency labs, cause

NORMAL PT, PTT, TT
Heparin deos NOT increase PTT

AD or acquired (proteinuria)

29

hodgkins subtypes

Nodular sclerosing: M=F, 70%, cervical or mediatinal, lacunae

Lymphocyte risk: good Px

Mixed or Lymphocyte depleted: bad Px

30

painless waxing and waning LAD

follicular (NHL); 14;18 bcl-2

31

lytic bone lesions, hypercalcemia, skin rash, generalized LAD with HSM
IVDA, japan/caribbean/west africa

adult T-cell lymphoma (NHL); HTLV-1

32

mycoses fungioides vs. sezary syndrome
[T-cell NHLs]


Histo

MF = cutaneous patches/plaques ("pautrier microabscesses"), LYMPHOMA
SS = cutaneous and systemic, LEUKEMIA


Criberiform nuclei in atypical CD4+ cells

33

MM vs MGUS vs WM

MM = IgG (MC) or IgA M-spike with CRAB s/s

MGUS = IgG or IgA spike with NO s/s (can become MM)

WM = IgM M-spike, hyperviscocity syndromes (blurred vision, raynauds)

34

Pseudo-Pelger-Huet anomaly

bilobed PMNs, seen after chemo

35

B-ALL: markers

T-ALL: markers

B-ALL = tdt, CD10, CD19, CD20

T-ALL = tdt, CD2,3,4,5,7,8

36

t(12;21)

good prognosis of ALL

37

CD5+ B-cell cancers

NHL mantle cell
CLL/SLL

38

smudge cells and AHA

CLL/SLL

39

Cancer ages

ALL - 60
Hairy - adults (b-cell)
AML - >65 (alk chemo, radiation, myeloprolif disorders, also downs); DIC
CML - 45-85 (low LAP; blast crisis = ALL/AML)

40

kid with skin rash, lytic bone lesions, recurrent otitis media with mastoid mass

Lanterns cell histiocytosis
S-100 and CD1a
Birbeck granules

types: names = malignant; 2 = 3yrs (with DI and exophthalmos)

41

ectopic EPO

RCC
HCC
hydroneophrosis

42

HIT

IgG--------heparin-PF4

43

AE ticlopidine

(ADP-R blocker)
neutropenia - fever and mouth ulcers

44

DOC intermittent claudication

cilostazole/dipyridamole


- PDE3 inhibitor .: increase cAMP in platelets .: prevents aggregation
- direct vasodilation

AE = headache, flush