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Flashcards in Micro - Viruses Deck (31):
1

recombination vs. reassortment

recomb = non-fragmented chromosomes (adenovirus)
reass = segmented genomes (influenza)

2

killed vaccine

Rabies
Injected influenza
Polio Salk (IM)
HepA

3

DNA viruses:

Hepadna, Herpes, Adeno, Parvo, Pox, Papilloma, Polyoma

Most are dsDNA and linear and icosahedral and replicate in nucleus and directly infectious

ssDNA = parvovirus
circular = papiloma, polyoma (JC + BK), hepadna (HBV)
complex = pox
replicate in cytosol = pox - carries an RNA pol
Not directly infectious = pox and HBV

4

RNA viruses:

Most ssRNA
- reoviridae is dsRNA (colti, rota)

+ve:
retro
toga
calici
corona
picorna
flavi
hepe

5

Directly infectious

all +ssRNA
all dsDNA (except pox and HBV)

6

Where do DNA viruses replicate

nucleus (except pox)

7

Where do RNA viruses replicate

cytosol (except influenza and retroviruses i.e. HIV)

8

naked =

DNA = PAPP
[papilloma, adeno, parvo, polyoma]

RNA = CPR HepE
[calici, picorna, reo, HepE]

9

Where do viruses get their envelopes

PM

[exception = herpes = nuclear membrane]

10

adenovirus s/s

febrile phayngitis
conjunctivitis
pneumonia
acute hemorrhagic cystitis

11

parvovirus s/s

- fetus = hydrops fetalis
- kids = fifth disease/erythema infectiosum/slap cheek (get lacy rash after)
- kid with sickle = aplastic crisis
- adults = pure red cell aplasia with RA-like symptoms

12

HPV strains

high risk = 16, 18, 31, 33

low risk = 1, 2, 6, 11

13

polyoma virus

JC - PML

BK - transplants

14

EBV infects B cells via

CD21

15

EBV vs CMV histo

EBV = downey cells (reactive T-cells)
CMV = owl-eye

16

Segmented RNA viruses

BOAR

Reoviruses - colti and rota
Orthomyxoviruses - influenza
Arenaviruses - LCMV and lassa fever
Bunyaviruses -
- Arbociruses: california encephalitis, sandfly/rift valley fevers, crimran-congo hemorrhagic fever
- Non-arbo: Hantavirus (hemorrhagic fever and pneumonia)

17

Non-segmented RNA viruses

Picorna - PERCH
Hepe
Calici - norwalk
Flavi - HCV, yellow fever, dengue, st. louis encephalitis, west nile
Toga - rubella, Eastern and Western equine
Retro - HIV, HTLV
Corona - corona
Paramyxo - Parainfluenza, RSV, measles, mumps
Rhabdo - rabies
Filo - Ebola/marburg
Delta - HDV

18

All RNA viruses

ds: reo

+ss:
toga, retro, calici, corona, picorna, flavi, hepe

-ss:
ABPOFR = arena, bunya, paramyxo, orthomyxo, filo, rhabdo
*need to bring their own RNA-dependent RNA-pol

19

Yellow fever s/s

Flavi; +; enveloped

high fever, black vomit, jundice
councilman bodies (viral injury of hepatocytes)

20

F (fusion) protein

paramyxoviruses (parainfluenza, RSV, mumps, measles)
causes respiratory epithelial cells to fuse into multinucleated cells

Block with palivizumab to prevent RSV pneumonia in premature infants

21

virus with pulsus paradoxus

croup (parainfluenza)

22

Warthin-Finkeldey giant cells

fused lymphocytes in measles

23

vitamin against virus

Vitamin A for measles

24

rabies stuff

binds ACH-Rs
Negri bodies
purkinje cells of cerebellum and hippocampal neurons

25

cells hit by ebola

endothelial, hepatocytes, phagocytes

26

DNA pol with DNA and RNA dependent functions

HepB

27

bad Hep for pregnant peope

HepE - fulminant liver failure

28

marker during HepB window period

HBc-Ab
IgM = recent/acute
IgG = part or CHRONIC

29

HBe =

infectivity

30

HIV genes and products:

env = gp120 (binds CD4+) and gp41 (fusion and entry)
- binding needs co-R = CCR5 on macrophages or CXCR4 on T-cells
- gp120 crosses placenta .: FP in babies
pol = RT, aspartate protease, integrase
gag = capsid

31

viruses that can make polyprotein product that then get cut up

RNA
+ss
linear
non-segmented