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Flashcards in MSK/Derm Deck (46):
1

SEE RYANS DECK FOR ANATOMY/NERVES

SEE RYANS DECK FOR ANATOMY/NERVES

2

Things that shorten in muscle contraction

HIS:
H = just myosin
I = just actin
S = sarcomere

3

Type I muscle fibres

Slow twitch
red
ox-phos - mitochindria and myoglobin

4

Ca+ channel on smooth muscle

L-type VG

5

FGFR-3 constituitive activation effect:

INHIBITION of chondrocyte proliferation

6

defective bone resorption

Osteopetrosis

7

Defective bone mineralization

Osteomalacia/rickets (with high ALP)

8

high ALP alone

Pagets

9

High ALP with low Ca, low PO4, and high PTH

Osteomalacia/rickets

10

causes of aseptic necrosis

Alcoholism
Sickle/Storage (Gauchers)
Endo/exo steroids
Pancreatitis
Trauma
Idiopathic (legg-calve-Perthes)
Caissons

11

Tumour@ epiphysis:

Giant cell:
- benign - osteoclastoma
- 20-40
- soap bubbles

12

Tumour @ metaphysis:

Osteochondroma:
- benign
- males 65
- via pagets, p53, Rb, infarcts, radiation
- codman's triangle/sunburt

Osteomyelitis

13

Tumour @diaphysis

Ewing sarcoma:
- malignant
- males

14

MCP involvement

RHEUMATOID ARTHRITIS

15

Random causes of gout

Thiazies - compete for transporters
Von Geirkes - lactic acidosis, compete for transporters
leish nyhan or PRPP excess - overproduction

16

pseudogout crystals

calcium PPi = chondrocalcinosis

17

pseudogout epidemiology

OA, hyperPTH, hemachomatosis

18

Gonococcal artritis triad

STD:
synovitis
tenovitis
dermatitis

19

ankylosing spondylitis associations

uveitis
aortic regurg

20

Reiters epidemiology

chlamydia
GI: shigella, salmonella, yersinia, campylobacter, c. diff

21

hypercoaguable with paradoxical increase in PTT

SLE

22

Anti-PL syndrome Abs

lupus anticoagulant
anticardiolipin
anti-b2 glycoprotein

23

FP tests with anti-PL syndrome

VDLR
long PTT

24

increased CD4:CD8 ratio

Sarcoidosis

25

Shaumann and asteroid bodies

sarcoidosis

26

Polymyalgia rheumatica

- pain and stiff shoulder and hip gurdles
- fever, malaise, weight loss, ESR, CRP
- women >50
- associated with temporal arteritis

- NO weakness, NO CK

27

Fibromyalgia

- widesread MSK pain with stiffness, paresthesias, poor sleep, fatigue
- young women 20-50
- rx = exercise, antidepressants, anticonvulsants

- NO inflammation so no markers

28

Polymyositis

- symmetrical proximal muscle weakness (shoulders)
- ENDOmysial inflammation
- CD8
- CK, ANA, anti-Jo, anti-SRP, anti-Mi-2

29

Dermatomyositis

- like polymyositis, BUT CD4 and PERImysial
- malar rash, helicotrope (eyes), "shawl and face", grottons papules, mechanic hands
- increased risk of GU cancers

30

proximal muscle weakness with autonomic shit

Lambert-Eaton

31

MCCD scleroderma

pulmonary sclerosis (pulm HTN)
[also renal, CV, GI sclerosis]

32

cleft palate via

primary palate (intermaxillary segment) and secondary palates (maxillary prominences) fail to fuse
OR
if secondary palates fail to fuse together

[cleft lip = intermaxillary segment and maxilary prominences, but NOT the palate part)

33

Inheritance of male-pattern baldness

polygenic inheritance with variable penetrance

34

common peroneal nerve split functions

deep = anterior leg muscles (dorsiflex foot) and sensation between toes 1 and 2

superficial = lateral leg muscles = evert foot and sensation to most of foot dorsum

35

parakaratosis

hyperkaratosis (increase SC thickness) with retention of nuclei

36

acanthosis

stratum spinosum hyperplasia

37

cholasma/melasma

hyperpigmentation of pregnancy/OCP

38

intradermal vs junctional nevi

intradermal = papule
junctional = macule

39

ssss histo

Stratum granulosum keratinocyte attachments destroyed

40

TEN histo

dermal-epidermal junction destroyed

41

eosinophils in blistering disorder

bullous pemphigoid

42

acanthosis nigracans associated with:

hyperinsulinemia
visceral malignancies (gastric ACA)

43

sawtooth lymphocyte infiltrate at dermal-epidermal junction

Lichen planus

44

Basal cell CA

ulcerating with rolled boarders
telangectasias
pallisading nuclei

45

SCC

sunlight, immunosuppression, irritation, arsenic
keratin pearls

actinic keratosis - precursor, rough, can horn
keratoacanthoma - variant that spontaneously regresses

46

Melanoma

S-100

variants:
- superficial spreading
- nodular (bad)
- lentigo malinga
- acral lentiginous (no UV relation)