Immuno Flashcards Preview

LAST MINUTE! > Immuno > Flashcards

Flashcards in Immuno Deck (43):
1

axillary nodes drain

all skin above diaphragm, breast, arm

2

superficial inguinal drains

all skin below umbilicus including lower anal canal and scrotum; except popliteal territory (post. calf + DL foot)

3

S's in skine skies

s. pneumo
salmonella
GBS

4

PAMPs

bound by TLC in innate immunity i.e. by NK cells
ex: LPS, flagellin, ssRNA

5

TAP proteins

MHC-I
bring Ag from protasome to ER to get bound

6

Invariant chain

MHC-II
Blocks binding site in vesicle until fusion with PL

7

CD16

on NK cells, binds to Fc of bound IgG inducing ADCC

8

activate NK with:

IL-2, IL-12, IFN-a, IFN-b

9

activation of TH17

IL-6, TGF-b, STAT-3

10

activation of T-cells co-stim:

APC B7------CD28 T-cell (h or c)

11

activation of B-cells co-stim:

Th CD40L--------CD40R B-cell

12

cytokines inducting:
- IgG
- IgA
- IgE

- IgG = IL-4
- IgA = IL-5, TGF-b
- IgE = IL-4 + IL-13

13

inducer of APRs

IL-6

14

CRP functions:

opsonin
fixes complement
facilitates phagocytosis

15

Down regulated APRs:

albumin
transferrin (taken up by macro to hide Fe)

16

Inhibitors of complement

DAF (DC55) and CI-esterase inhibitor

17

anaphylaxis signals

via complement activation: C3a C4a C5a

18

Macrophage markers

CD14 - (aka TLR4) binds lipid A of LPS
CD40 - binds CD40L of Th
B7 - binds Th/Tc to activate them
Fc-R and C3b-R - phagocytosis

19

NK markers

CD16 - ADCC by binding Fc of IgG
CD 56 - marker

20

superantigens mechanism

crosslink TCR and MHC-II
thus can activate ANY t-cell

21

HST resulting in systemic symptoms and vasculidities

Type III

22

transfusion reactions:

to plasma proteins = allergic or anaphylactic (IGA defic.)
to HLA Ag and WBCs = febrile non-hemolytic
to RBCs = acute hemolytic

23

anti-centromere

CREST

24

polymyositis/dermatomyositis Abs

Anti-Jo
Anti-SRP
anti-Mi-2

25

PBC ab

anti-mitochrondrial

26

scleroderma abs

Anti-Scl-70
anti DNA topo-I

27

anti-sm

autoimmune hepatitis

28

anti-CCP

RA

29

ASCA

Chrons

30

No B-cell + no IGs vs. no plasma cells + no Igs

No B = BTK deficiency (Bruton's agammaglobulinemia)
No plasma = combined variable immunodeficiency

31

IL-12-R deficiency

systemic fungal and mycobacteria infections because macrophages releasing IL-12 does nothing

AR

32

Job syndrome

hyper IgE - AD
STAT-3 mutation, no TH17, so PMN chemotaxis or IgE down regulation
Facies, cold abscesses, eczema, retained teeth

33

low TRECs

SCID
also no thyme shadow, germinal centrism or T-cells
do NOT give live vaccines!
Get every type of infection

34

immune defic. with high AFP

Ataxia telangectasia
low IgA, IgG, IgE

35

immune defic. with thombocytopenia

W.A
triad = thrombocytopenia, eczema, recurrent infections
also autoimmune diseases and malignancies
via actin cytoskeleton problem
*low IgG and IgM
*high IgA and IgE

36

high IgE

Job
W.A (also high IgA)

37

delayed umbilical cord separation

LFA-1 (CD-18) defic.
LAD

38

albanism + neuro

chediak higashi; LYST
pancytopenia

39

Nitroblue tetrazolium dye test yellow

CGD
make granulomas because can't kill them with res. burst

40

graft thrombosis with ishcemia/necrosis

Hyperacute; preformed Abs

41

graft vasculitis with dense intersitial lymphocyte infiltrate

acute; CD8

42

proliferation of vascular SM with parenchymal atrophy and interstitial fibrosis; AS

chronic; CD4 (cytokines)

43

post-graft jaundice, rash, diarrhea, HS_megally

GVHD
liver and BM transplants