Heme path 1

Question 1

poor prognosis in CLL

Answer 1

CD38 and ZAP70 positive

del(11q), del(17p), Tri 12

Question 2

Good prognosis in CLL

Answer 2

del(13q)

Question 3

Bone marrow in hairy cell

Answer 3

reticulin fibrosis with dry tap

Question 4

Phenotype of Hairy cell

Answer 4

Bright
CD11c, CD25, CD103
Annexin A1, TRAP, DBA.44

Question 5

CD20 in CLL

Answer 5

dim

Question 6

BCL2 in cutaneous follicular lymphoma

Answer 6

often negative

Question 7

t(14:18)

Answer 7

90% of FL

Question 8

Translocation in FL

Answer 8

t(14;18)

Question 9

FL in peripheral blood

Answer 9

buttock cells

Question 10

phenotype of Mantle cell

Answer 10

nuclear cyclinD1 (80%), CD20, CD5, CD43, BCL-2

Question 11

translocation in mantle cell

Answer 11

t(11:14) BCL1-IGH

Question 12

t(11;14)

Answer 12

mantle cell

Question 13

morphology of marginal zone

Answer 13

monocytoid, plasmacytoid, dutcherbodies, lymphoepithelial lesions

Question 14

translocation in MALT

Answer 14

t(11;18) MLT-API2

Question 15

t(11;18)

Answer 15

MALT (25-50%)

Question 16

risk factors for extranodal marginal zone lymphoma

Answer 16

H.pylori
sjogren
hashimoto
Hep C
Borrelia burgdorferi (in skin)
Campylobacter (in eye)

Question 17

Definition of Waldenstrom

Answer 17

LPL with IgM monoclonal gammopathy

Question 18

Clinical presentation of LPL

Answer 18

hyperviscosity, neuropathy, cryoglobulinemia

Question 19

Three translocations in Burkitt

Answer 19

t(8;14) IgH/myc
t(2;8) myc/kappa
t(8;22) myc/lambda

Question 20

Oct2 and BOB1 positive in

Answer 20

NLPHL

Question 21

Tcells ringing malignant cells in NLPHL

Answer 21

CD3+, CD57+

Question 22

Hodgkin with highest percentage of EBV positivity

Answer 22

mixed cellularity

Question 23

Hodgkin with lower percentage of mediastinal involvement

Answer 23

mixed cellularity

Question 24

HL with regressed germinal centers

Answer 24

lymphocyte rich

Question 25

Location of RS cells in lymphocyte rich HL

Answer 25

mantle zone

Question 26

Tcell lymphomas occuring in LNs (3)

Answer 26

1. Peripheral T cell lymphoma, NOS 2. Angioimmunoblastic 3. Anaplastic large cell lymphoma

Question 27

Tcell lymphomas occurring as leukemia/bone marrow involvement (5)

Answer 27

1. adult Tcell leukemia 2. T cell prolymphocytic leukemia 3. T cell LGL leukemia 4. Aggressive NK/Tcell leukemia 5. T cell lymphoblastic leukemia

Question 28

Extranodal T cell lymphomas (7)

Answer 28

1. enteropathy assd 2. Hepatosplenic 3. Extranodal NK/Tcell 4. Subcutanous panniculitis-like T cell lymphoma 5. Gamma-delta T cell lymphoma 6. Mycosis fungoides 7. primary cutaneous CD30+ T cell lymphoproliferative dz

Question 29

Morphologic clues to T cell origin

Answer 29

Clear cytoplasm and eosinophils