Immunology 3 Flashcards
(25 cards)
Common variable immunodeficiency has decreased
IgG, IgM, IgA
clinical presentation of CVID
recurrent upper and lower resp infections, bronchiectasis, Giadiasis
Histology in CVID
Hypoplastic germinal centers
no plasma cells
clinical of selective IgA deficiency
respiratory and GI bacterial infection
autoimmunity
Job syndrome
hypergammaglobulin E
clinical of Job syndrome
susceptible to Staph, eosinophilia, eczema
DiGeorge genetics
del 22q (or del 10p)
Del 22q assd with what conditions
DiGeorge,
Velocaridalfacial
Shprintzen syndrome
DiGeorge clinical
hypercalcemia
hypoplastic thymus and parathyroids,
typical facies
great vessel anomalies
histology in DiGeorge
depleted paracortex, decreased PALS in spleen
SCID genetics
50% X-linked, defect IL-2 receptor
40% AR, adenosine deaminase deficiency
SCID clinical
absent Tcells, undetectable Ig, thymic dysplasia
Wiskott-Aldrich triad
ezcema, thrombocytopenia, immunodeficiency
Infections is W-A
encapsulated bacterial, pneumocystis, herpes
12% incidence of what in W-A
fatal malignancies
Immunodeficiency in W-A
Tcell and Bcell
Ataxia-telangiectasia (lous-Barr) genetics
AR, ATM gene 11q
Duncan disease genetics
X-linked lymphoproliferative disease
SH2D1A gene
SAP protein
Duncan disease clinical
fatal immune response to EBV
hemophagocytic syndrome
Integrin defiencines
LF-1 or MAC-1
periodontisi and delayed cord separation
Jordan anomaly
vacuolization of leukocyte cytoplasm by fat
classica complement deficineces (C1q, C2, C4) cause
autoimmune diseases (lupus)
C2 or C3 deficiency
G+ encapsulated organisms
C1 esterase inhibitor deficiency
hereditary angioedema
