Autoimmunity 1 Flashcards by Casey Gooden

Q

ANA homogenous pattern

A

dsDNA, ssDNA, histone

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Q

ANA rim pattern

A

dsDNA

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Q

ANA speckled

A

Sm, RNP, Scl70, SS-A/B

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Q

ANA nucleolar

A

scleroderma

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Q

ANA centromere

A

CREST

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Q

ANA cytoplasmic

A

AMA, ASMA

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Q

Anti-dsDNA can be detected by indirect immunoassay using what substrate

A

Crithidia luciliae

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Q

Anti-dsDNA dz

A

SLE

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Q

Anti-histone dz

A

drug-induced lupus

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Q

Anti-Jo1 dz

A

interstitial lung dz in poly/dermatomyositis

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Q

Anti-Sm dz

A

SLE

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Q

Anti-RNP dz

A

mixed connective tissue disease

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Q

Anti-nucleolar dz

A

scleroderma

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Q

ANti-SSa/b dz

A

sjogren

neonatal lupus

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Q

Anti-mitochondrial dz

A

PBC

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Q

Anti-Liver kidney microsomal dz

A

autoimmune hepatitis

Q

Anti-Smooth muscle dz

A

autoimmune hepatitis

Q

ANti-microsomal dz

A

Hashimoto»>Graves

Q

Anti-endomysial dz

A

celiac, DH

Q

Anti-centromere dz

A

CREST

Q

Anti-IF dz

A

polymyositis/dermatomyositis

Q

Anti-Scl 70 dz

A

progressive systemic sclerosis

Q

cANCA dz

A

Wegener (anti-proteinase 3)

Q

Anti-thyroglobulin dz

A

Hashimoto

Thyroid stimulating Abs dz

Graves

Anti-parietal cell dz

most sensitive for pernicious anemia

ANti-intrinsic factor dz

specific for pernicious anemia

What virtually excludes active SLE

negative ANA

Increasing anti-dsDNA predicts

SLE flare

ANti-dsDNA and anti-Sm are essentially restricted to

SLE

Drugs causing lupus

hydralazine, procainamide, isoniazid