Hepatitis II Flashcards Preview

Micro Post Midterm > Hepatitis II > Flashcards

Flashcards in Hepatitis II Deck (33):
1

what does large form HDAg do

-suppresses HBV replication
-packages the HDV genome

2

what does small form HDAg do

transactivating the replication of HDV genome

3

what marker is elevated in Hep D

alanine amino transferase ALT
also high in Hep C

4

what does infection with Hep D interfere with

activation of an early step in the JAK STAT signal transduction pathway

5

how is Hep D diagnosed and control

anti delta IgM or anti delta IgG
control by controlling Hep B with vaccination

6

treatment of Hep D

higher doses of longer duration of IFNalpha
IFNalpha destroys RNA which is the genome of Hep D

7

which of the hepatitis has a high mortality in pregnant women

Hep E

8

does Hep E develop into fulminant hepatitis

it is usually self limiting and very seldom does it develop into fulminant hepatitis

9

treatment of Hep E

inteferon and ribavirin

10

type of hepatitis caused by Hep G

syncytial giant cell hepatitis

11

transfusion transmitted hepatitis

Hep TT and Hep C

12

genome in Yellow Virus

flavivirus so +ssRNA

13

where is yellow virus common and how is it transmitted

Africa - aedes aegypti mosquitoes
South America - haemagogus mosquitoes

14

clinical features of yellow virus

within a week, abrupt fever, myalgia, prostration and it resolves in 5 days

15

clinical features seen in severe yellow virus infection

fever, jaundice, bleeding seen with hematemesis, collapse

16

how do you diagnose and prevent yellow fever

diagnose with serology or PCR
live attenuated 17D strain of yellow fever or control mosquito population

17

clinical features of epstein barr virus (HHV-4) causing herpes

fever, atypical lymphocytosis

18

how is HHV-4 diagnosed

-atypical lymphocytes/downey cells in peripheral blood
-slightly elevated ALP

19

genome of herpes virus HHV-4 and HHV-5

linear dsDNA

20

how is HHV-5 aka cytomegalovirus transmitted

urine, saliva, breast milk, semen, genital secretion

21

how is HHV-5 diagnosed

-cytomegalic cells (owl's eye)
-cotton wool retina (CMV retinitis)
-virus isolation from saliva and urine
-EM observation in urine
-RIA and ELISA

22

what is cytomegalovirus resistant to and why

acyclovir because it does not have thymidine kinase to activate it

23

what is used to treat HHV-5

gancyclovir and human leukocyte interferon

24

organisms involved in bacterial hepatitis -- though rare

leptospira
coxiella burnetii
brucella
mycobacteria

25

what is leptospirosis

zoonosis in which bacteria comes from urine of infected animal like rats, cattles, pigs, rodents, dogs

26

how is leptospirosis transmitted

contact with contaminated water after heavy rains or flood

27

most common species of leptospirosis

leptospira interrogans

28

what severe disease can arise from leptospirosis

severe weil disease

29

hepatitis due to parasites

echinococcus multiocularis
echinococcus granulosus

30

biliary obstruction due to parasies

echinococcus multiocularis
echinococcus granulosus
fasciola hepatica

31

in echinococcus granulosus, larvae form slow growing tumor like structure laminated in a membrane called

hydatid cyst

32

intermediate hosts of the echinococcus

multiocularis - rodents
granulosus - sheeps, goats, horses, camels, swine

33

definitive hosts of the echinococcus

multiocularis - foxes
granulosus - dogs