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Flashcards in UGI 3 Deck (22):
1

common site of gonorrhea infection in men and women and associated symptom

men: urethra; purulent urethral discharge
women: cervix; vaginal discharge

2

clinical presentation of gonorrhea

vaginal and urethral discharge, erosive vesiculobullous lesions, mucopurulent gonococcal cervicitis

3

features of neisseria gonorrhea

gram neg diplococci, non motile non spore forming, fastidious, oxidase positive,

4

virulence factor of neisseria gonorrhea

pili, Opa, por protein, LOS, iron binding protein
LIPOP

5

pathogenesis of neisseria gonorrhea

it binds to columnar epithelial cells of distal cervix or urethra using PILI and outer surface proteins then multiplies

6

in women gonorrhea spreads to the fallopian tube. how does it spread if its not motile?

uterine or urethral contractions

7

what can chronic infections of neisseria gonorrhea lead to

scarring and stricture of fallopian tube or urethra

8

how do you diagnose gonorrhea

1. intracellular gram neg diplococci for women only
2. non culture lab test
3. thayer martin or chocolate agar with oxidase pos colonies

9

treatment of gonorrhea

250mg single dose of ceftriaxone together with 1g oral azithromycin

-there is resistance to fluoroquinolones so can only see cephalosporin (beta lactamase resistant)

10

when treating gonorrhea what else do you treat for

chlamydia since a good portion of people have both

11

increases the transmission of HIV

bacterial vaginosis, trichomoniasis, gonorrhea, chlamydia

12

most commonly reported notifiable disease

chlamydia

13

chlamydia trachomatis is associated with what disease

conjunctivitis, infant pneumonia, urogenital disease (D-K)
lymphogranuloma venerum (LGV1, 2, 3)

14

since chlamydia is mostly asymptomatic, it often goes untreated. What could happen if chlamydia goes untreated in women

they can develop PID (pelvic inflammatory disease) which leads to infertility, ectopic pregnancy, chronic pelvic pain

15

what happens if men have chlamydia that goes untreated (though this is rare)

epididymitis and urethritis

16

features of chlamydia

-gram neg but atypical bacteria
-infectious form - elementary bodies
-replicative/non infectious form - reticulate bodies
-obligate intracellular
-gains entry via ulceration and laceration

17

why can't you view chlamydia with a gram stain although it is gram neg

it is atypical in that it is intracellular

18

receptors for elementary bodies

– mucous membranes of the urethra
– endocervix, endometrium, fallopian tubes
– anorectum
– respiratory tract and conjunctivae

19

specimen used for testing in chlamydia

-urine or swab from urethra if male and vagina or endocervix if female
-for those that engage in anal or oral sex, rectum and oropharynx swab

20

best test for chlamydia

NAAT (like in trichomoniasis)

21

why are swabs and not exudate used as specimen for chlamydia

because it is an intracellular parasite

22

treatment for chlamydia

-azithromycin 1g orally, single dose
-doxycycline 100mg orally 2x/day for 7 days