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Flashcards in Parasites Deck (25):
1

predilection site for plasmodium

RBCs

2

predilection site for leishmania

WBC

3

predilection site for all trypanosomas

plasma

4

predilection site for schistosoma mansoni and japonicum

mesenteric vein

5

predilection site for schistosoma haematobium

veinous plexous of bladder

6

treatment for American Trypanosomiasis

Benznidazole and Nifurtimox

7

when does the treatment for American Trypanosomiasis work

they only work on trypomastigote phase and in the acute phase hence why screening is so effective

8

what phase does Benznidazole and Nifurtimox not work

in the amastigote phase

9

is there a vaccine for American Trypanosomiasis

no

10

treatment for African Trypanosomiasis

Suramin or Eflornithine

11

downside of Suramin or Eflornithine as treatment for African Trypanosomiasis

it removes tryps from everywhere except the CNS

12

treatment for the CNS for African Trypanosomiasis

Melarsoprol (crosses the BBB)

13

what is used to control the vector of African Typanosomiasis

biconical trap is used to control the tsetse population

14

downside to biconical trap

as the tsetse population falls, there is an increased lack of interest to keep up with the control of the vector ---> decrease in biconical trap ---> tsetse population increases again

15

what is the leishmania that leads to systematic/visceral disease

L. donovani

16

what are the leishmania that leads to cutaneous localized disease

L. majora, L. Tropica, L. aethiopica
CUT MAT

17

how does L. braziliensis work

it starts localized then later becomes metastatic mucocutaneous disease

18

treatment for leishmaniasis

-Amphoteracin B
-Pentavalent Antimonial compounds
(Sodium stibogluconate - Pentostam)
-Paramomycin
-Miltefosine

LAMPP

19

screening of leishmaniasis

clinical and rK39 dipstick

20

what is seen in old world cutaneous caused by L. major

small red papule which ulcerates after 2 weeks with serous exudate

21

what is seen in old world cutaneous caused by L. tropica

oriental sores
small red papule which ulcerates after 2-4 months --> dry ulcers

22

how does L. tropica heal and what happens after it heals

it heals spontaneously after in 2-3 months then patient is able to mount a cellular immune response so parents tend to put kid next to sand hill so they can be bit in a not so obvious place like the ankles and can build immunity and not have the ulcers in a place so obvious like the face

23

what is seen in new world mucocutaneous leischmaniasis caused by l. braziliensis

small cutaneous papules that for ulcers months later and heal with a scar and are asymptomatic

24

what happens years later with l. braziliensis

the parasite stays later then 3-20 years later, very destructive oral and nasal lesions develop

25

how do you control l. braziliensis

Flea collars on dogs
Treatment of infected individuals
Use of residual insecticides