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Flashcards in HF2 Deck (20)
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1

the Frank-Starlin Mechanism describes the relationship between what

relationship between preload and SV

2

describe Frank Starling Mechanism

the more volume left in the heart the more the muscles stretch, increasing contractility

3

what is the problem with remodeling and hypertrophy

as heart muscle gets bigger, less room for ventricular blood volume

4

what modulates volume and vascular tone via SNS and RAAS

neurohumoral activation

5

what is another name for end diastolic pressure

preload

6

in HF, the Frank-Starling relationship shows what problem?

increased volume does not properly increase CO (cardiac output)

7

what drug is known for positive inotropic effect

digoxin

8

how do ACEI's help normalize Frank-Starling relationship

decreasing afterload giving more CO

9

beta activation due to baroreceptor reflex causes what to be released

renin

10

what is increased aldosterone levels do to preload or afterload levels?

increase preload

11

what are the 3 drugs with proven mortality reduction

ACE inhibitors
Beta blockers
Spironolatone

12

what is the MOA of spironolactone

competitive antagonist at aldosterone receptor

13

what is the MOA of dobutamine on HF?
hemodynamic effects?

MOA= stimulate B adrenergic receptors
hemodynamic effect = decrease preload (B2 effect) and increase contractility (B1 effect)

14

water restriction has what intravascular effect

decrease preload

15

what is the MOA of digoxin

inhibit Na/K ATPase
increasing intracellular Ca
increasing contractility

16

what are the hemodynamic effects of inamrinone and milrinone

increase contractility
decrease preload
decrease afterload

17

what are the hemodynamic effects of ACEIs

decrease afterload decrease preload

18

what are the hemodynamic effects of nitrates

decrease preload

19

what are the hemodynamic effects of spironolactone

decrease preload

20

what are the hemodynamic effects of digoxin

increased contractility