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Flashcards in HTN5 Deck (11)
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1

when should first dose of alpha-blockers be taken?
why?

before bed
orthostatic hypotension

2

what are the adverse effects of alpha blockers

sodium and water retention
headache
orthostatic hypotension
reflex tachycardia

3

what is the MOA of alpha blockers on HTN

vasodilation at resistance arterioles

4

list 4 alpha-2 agonists

1. methyldopa
2. clonidine
3. guanabenz
4. guanfacine

5

what does stimulation of alpha2 receptors do

decreases presynaptic release of NE,
decreasing vasoconstriction

6

how is methyldopa eliminated?

renal elimination

7

what are some adverse effects of methyldopa

sedation
depression

8

list the sines and symptoms of clonidine withdrawal

Sweating
Headache
Elevated bp
Nervousness
Tachycardia

9

why should clonidine withdrawal not be treated with a B-Blocker alone?

clonidine works at alpha2 and blocks a-1, b-1, b-2.
BB's block b-1 and b-2, but a-1 is unblocked and leads to vasoconstriction, while BB effect of decreased CO can cause HF

10

name an adrenergic blocking agent

reserpine

11

what does reserpine inhibit?
what does this do?

inhibits VMAT
decreases storage of NE and DA