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Flashcards in HTN5 Deck (11)
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1
Q

when should first dose of alpha-blockers be taken?

why?

A

before bed

orthostatic hypotension

2
Q

what are the adverse effects of alpha blockers

A

sodium and water retention
headache
orthostatic hypotension
reflex tachycardia

3
Q

what is the MOA of alpha blockers on HTN

A

vasodilation at resistance arterioles

4
Q

list 4 alpha-2 agonists

A
  1. methyldopa
  2. clonidine
  3. guanabenz
  4. guanfacine
5
Q

what does stimulation of alpha2 receptors do

A

decreases presynaptic release of NE,

decreasing vasoconstriction

6
Q

how is methyldopa eliminated?

A

renal elimination

7
Q

what are some adverse effects of methyldopa

A

sedation

depression

8
Q

list the sines and symptoms of clonidine withdrawal

A
Sweating
Headache
Elevated bp
Nervousness
Tachycardia
9
Q

why should clonidine withdrawal not be treated with a B-Blocker alone?

A

clonidine works at alpha2 and blocks a-1, b-1, b-2.

BB’s block b-1 and b-2, but a-1 is unblocked and leads to vasoconstriction, while BB effect of decreased CO can cause HF

10
Q

name an adrenergic blocking agent

A

reserpine

11
Q

what does reserpine inhibit?

what does this do?

A

inhibits VMAT

decreases storage of NE and DA