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Flashcards in HTN4 Deck (40)
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1

what are the 4 classes of sympathoplegic agents for HTN?

1. Beta-Blockers
2. Alpha-1 Blockers
3. Alpha-2 Agonists
4. Adrenergic blocking agents

2

ACE-I's are eliminated where, except for which one is hepatically eliminated

all renally eliminated
except fosinopril has some hepatic elimination

3

nitric oxide has what effect on PVR

decreases PVR
(nitric oxide is a vasodilator)

4

what catecholamine receptors are found on the presynaptic cell?

alpha2

5

what receptors are on post synaptic vascular smooth muscle cells

alpha1 receptors

6

what receptors are responsible for chronotropic action

beta1

7

what receptor activation increases liver's release of renin

beta 1

8

what are beta blockers effect on chronotropic and inotropic effects?

decrease both

9

chronotropic effects refers to what specifically?

heart reate

10

inotropic effects refer to what specifically

stroke volume

11

list the adverse effects of beta blockers

HBBEEF
hypoglycemia
bradycardia
exacerbate heart failure
bronchoconstriction (B2 rec)
depression
ED
fatigue

12

how do BB's worsen HF?

by decreasing CO

13

which BB's are B1 selective

NEVER BE BAMA
Nebivolol
Bisoprolol
Betaxolol
Acebutolol
Metroprolol
Atenolol

14

why should BB's not be stopped abruptly

receptor upregulation leads to rebound hypertension

15

who should use BB's with caution

CHAD

COPD
Heart Failure
Asthma
Diabetes

16

what was the 1st BB?

propranolol

17

what drugs can interact with metoprolol

SSRI's
Bupropion
H2-antagonists

18

what is metoprolol's extended release form

metoprolol succinate

19

what is metoprolol's immediate release form

metoprolol tartrate

20

what type of metabolism does metoprolol go through?

hepatic metabolism
(CYP2D6)

21

how is atenolol primarily excreted

unchanged in urine

22

what 2 nonselective BB's are excreted in urine unchanged

nadolol and carteolol

23

name 2 cardioselective BB's other than metoprolol metabolized by CYP2D6

betaxolol and bisoprolol

24

name 2 cardioslective BB's dosed once daily due to long half life

betaxolol and bisoprolol

25

name 3 partial agonist BB's?

pindolol
acebutolol
penbutolol

26

define B-receptor partial agonist

binds to B receptor but produces little effect,
very little side effects
intrinsic sympathomoimetic activity

27

name a cardioselective partial agonist BB

acebutolol

28

what are the 2 inactive isomers of labetalol

SS and RS are inactive

29

what is the potent alpha-blocker isomer of labetalol

SR = potent alpha

30

what is the potent non-selective beta blocking isomer of latetalol

RR