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Pharmacology II > HTN6 > Flashcards

Flashcards in HTN6 Deck (38)
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1

what is clonidines effect on:
PVR, CO, HR, and SV

all decrease due to inhibition of NE binding a1, b1, and b2 receptors

2

if alpha1 receptor is stimualated what occurs?

increased vasoconstriction, increased PVR

3

beta blockade leads to what?

decreasaed HR
decreased SV

4

which antihypertensive agent would be most appropriate to treat HTN crisis due to clonidine withdrawal:
a. lisonipril
b. labetalol
c. esmolol
d. prazosin

c. labetalol

5

what are the 2 main groups of drugs for HTN considered vasodilators

Ca channel blockers
direct vasodilators

6

what is activated by Nitric Oxide in a vascular smooth muscle cell

guanylyl cyclase

7

what is the cascade stimulated by NO in vascular smooth muscle (3 steps after NO)

1. guanylyl cyclase converts GTP to cGMP
2. cGMP activates myosin-LC phosphatase
3. myosin-LC phosphatase causes relaxation

8

how does myosin-LC cause smooth muscle relaxation

by dephosphorylating myosin light chain

9

what CCB's have use dependent binding

nondihydropyrimidines

10

what CCB's have voltage dependent binding

dihydropyrimedines

11

what class is diltiazem

benzothiazepine

12

what class is verapamil

phenylalkilamine

13

what is the MOA of verapamil

blocks P-glycoprotein transporter, decreasing HR and FOC

14

dihydropyridines have what type of selectivity? what does it cause there

vasoselective, causing vasodilation

15

what CCB interacts with digoxin

verapamil

16

what dihydropyrimidine is available IV and can be used in HTN crisis

nifedipine

17

what type of CCB is associated with GI intolerance

non-dihydropyridines

18

what type of CCB is associated with tachycardia

dihydropyridines

19

what activates MLCK cascade for smooth muscle contration to take place

calcium

20

how is hydralazine metabolized

acetylation

21

what does tachyphylaxis mean

with repeated use, need a higher dose to get therapeutic effect

22

what is minoxidil's MOA

hyperpolarization by activating ATP modulated K channels

23

what are some adverse effects of minoxidil

hypotrichosis
salt and water retention
cardiac effects (increases HR, FOC, and O2 demand)

24

what oral vasodilator is also found in rogaine

minoxidil

25

what is the parenteral vasodilator that increases dephosphorylation of MLCK in smooth muscle

sodium nitroprusside

26

what is the MOA of sodium nitroprusside

donates NO causing vasodilation

27

what are 3 adverse effects of sodium nitroprusside

1. cyanide toxicity
2. flushing
3. headache

28

what is the MOA of diazoxide

activates K+ channels causing hyperpolarization

29

what is another use of diazoxide?
how?

treats hypoglycemia
inhibits secretion of insulin

30

what is the MOA of fenoldopam

activates dopamine receptors