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Flashcards in ischemia4 Deck (22)
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1

patients with coronary artery disease should avoid what

IR nifedipine
(only IR CCB)

2

nondihydropyridines can exacerbate what

HF by depressing cardiac function

3

diltiazem is contraindicated with what?

pulmonary congestion (acute MI risk)

4

verapamil is contraindicated with what (other than digoxin)?
why?

IV beta-blockers
(drastic decrease in HR)

5

why is verapamil contraindicated with digoxin

verapamil inhibits p-glycoprotein; increasing digoxin levels

6

what are the therapeutic uses of CCB's (we need to know 4)?

HAVE

Hypertension
Arrhythmia
Variant angina
Exercise induced angina

7

what CCB is used for migraine prophylaxis?

verapamil

8

what CCB is used for neuro deficits after aneurysm

nimodipine

9

what CCB is used for Raynauds disease

Felodipine
Amlodipine
Nifedipine
Diltiazem

10

what is the positive effect of CCB's for exercise induced angina treatment?

decrease oxygen demand
increase blood flow

11

what is first line for MI?

beta blocker

12

what is the benzothiazepine CCB

diltiazem

13

what is verapamil's structural class

diphenylalkylamine

14

what is diltiazems structural class

benzothiazepine

15

name two non racemic mixture CCB's

nifedipine and diltiazem

16

why do all the CCB's have pretty low oral bioabailability

extensive 1st pass metabolism

17

why is amlodipine a preferred CCB

it has a long half life; less reflex tachycardia

18

what dihydropyridine is IV only?

clevidipine

19

what is clevidipine's half life

2 minutes

20

name a diphenylalkylamine

verapamil

21

what dihydropyridine is used for it's neurological effects; helps ease deficits after brain injury
(not used for HTN)

nimodipine

22

what are CCB's main effect?
what individual beneficial effects does this have on the heart

arteriole dilation:
increases vasodilation
decreases afterload
decreases oxygen demand