Flashcards in ischemia4 Deck (22)
patients with coronary artery disease should avoid what
(only IR CCB)
nondihydropyridines can exacerbate what
HF by depressing cardiac function
diltiazem is contraindicated with what?
pulmonary congestion (acute MI risk)
verapamil is contraindicated with what (other than digoxin)?
(drastic decrease in HR)
why is verapamil contraindicated with digoxin
verapamil inhibits p-glycoprotein; increasing digoxin levels
what are the therapeutic uses of CCB's (we need to know 4)?
Exercise induced angina
what CCB is used for migraine prophylaxis?
what CCB is used for neuro deficits after aneurysm
what CCB is used for Raynauds disease
what is the positive effect of CCB's for exercise induced angina treatment?
decrease oxygen demand
increase blood flow
what is first line for MI?
what is the benzothiazepine CCB
what is verapamil's structural class
what is diltiazems structural class
name two non racemic mixture CCB's
nifedipine and diltiazem
why do all the CCB's have pretty low oral bioabailability
extensive 1st pass metabolism
why is amlodipine a preferred CCB
it has a long half life; less reflex tachycardia
what dihydropyridine is IV only?
what is clevidipine's half life
name a diphenylalkylamine
what dihydropyridine is used for it's neurological effects; helps ease deficits after brain injury
(not used for HTN)