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Pharmacology II > HTN1 > Flashcards

Flashcards in HTN1 Deck (26)
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1
Q

what is the normal category of BP according to JNC 7

A

<80

2
Q

what is the prehypertensive category of BP according to JNC 7

A

120-139 or 80-89

3
Q

what is the Stage 1 HTN category of BP according to JNC 7

A

140-159 or 90-99

4
Q

what is the stage 2 HTN category of BP according to JNC 7

A

greater than 160 or greater than 100

5
Q

what are the 2 types of HTN

A

primary/ essential HTN = idiopathic

secondary HTN

6
Q

what is the formula for BP

A

CO x PVR

7
Q

what are 3 types of arteries and arterioles

A
  1. splanchnic
  2. skeletal muscle
  3. renal
8
Q

what happens to PVR as the diameter of arteries decreases (vasoconstriction)

A

PVR increases

9
Q

will an increase or decrease on CO increase BP?

how bout an increase or decrease in PVR?

A

increase in CO increases BP

increase in PVR increases CO

10
Q

PVR or SVR is determined by what

A
  1. direct innervation
  2. circulating regulators
  3. local regulators
11
Q

CO is determined by what two factors

A

heart rate

stroke volume

12
Q

heart rate is determined by what?

A

parasympathetic nervous sytem
sympathetic nervous system
catecholamines

13
Q

what determines your SV (stroke volume

A
  1. contractility

2. preload

14
Q

what determines preload

A

venous tone

Intravascular volume

15
Q

list some local regulators that determine

A
HA A PEN
H+
Angio II
Adenosine
NO
Prostacyclin
Endothelin
16
Q

direct innervation of what receptors cause increase in SVR by vasoconstriction

A

alpha1 receptors

17
Q

what are the 4 mains sites of control of BP that can be triggeres

A
  1. arteriole resistance (constriction or dilation)
  2. Venule Capacitance (Preload)
  3. Heart pump Output
  4. Kidney Volume (intravascular vol.)
18
Q

what regulates short term BP control

A

baroreceptors and

sympathetic nervous system

19
Q

what activates baroreceptors

A

stretch in veins or arteries

20
Q

what regulates long term BP control

A

kidneys and

RAA system

21
Q

a decrease in blood pressures does what to:
1 sympathetic activity
2 renal blood flow
3 GFR

A

1 increase sympoathetic activity
2 decrease renal blood flow
3 decreasee GFR

22
Q

decrease blood flow has what sympathetic effect on what adrenoreceptors?

A

activates B1 receptros on the heart
activates alpha1 receptros of smooth muscle
activates adrenoreceptros on kidney

23
Q

what effect does activation of B1 adrenoreceptors on the heart have?

A

increases CO

24
Q

what effect does activation of alpha-1 adrenoreceptors on the smooth muscles have?

A

increased venous return and increased PVR

25
Q

what effect does activation of B1 adrenoreceptors on the kidney have?

A

increased Renin release

26
Q

what effect on BP does increased venous return have?

A

increase on BP