Flashcards in HF3 Deck (41)
what is the mechanism of action of clonidine
a. direct dilation of arterioles
b. selectively block alpha1 receptors
c. reduce sympathetic outflow from vasomotor centers in the brainstem
d. prevent the release of NE from peripheral postganglionic sympathetic neurons
c. reduce sympathetic outflow
which are the predominant initial effects of B1 antagonists
a. decrease HR and decrease FOC
b. decrease HR and decrease PVR
c. decrease PVR and decrease preload
d. decrease preload and decrease CO
a. decrease in HR and decrease in FOC
what is the most likely adverse effect of a drug that causes direct vasodilation of arterioles
list 4 groups known as preload reducers
3. aldosterone antagonists
what are diuretics effects on symptoms of HF and hypertrophy
decreases symptoms and decreases hypertrophy
which is an antidiuretic hormone antagonist:
name two aquaretics
what are the effects of auqaretics?
increase urine output, increase sodium concentration, decrease HF symptom,s, and effect BP
list two aldosterone antagonists that decrease preload
spironolactone and eplerenone
what is the MOA of aldosterone antagonists
decrease Na/ K exchange in collecting duct;
decreasing sodium and water reabsorption
what should be monitored when taking spironolactone?
list the venodilators.
what is there MOA
increase venous capacitance
what do venodilators do to venous return to heart and O2 demand
decrease venous return
decrease O2 demand
does sodium nitroprusside effect the arterial side or venous side more in a normal heart?
in normal heart venouse side
in HF arterial side
list 3 afterload reducing groups
what is the MOA of ACEIs and ARBs on preload side?
what is the MOA of ACEIs and ARBs on afterload side
blocks angio II's vasoconstriction
how does angio II have a slow pressor response
how does angio II have a rapid pressor response
other than decrease afterload and preload what hemodynamic effect does ACEI's and ARBs have?
decrease remodeling and decrease hypertrophy
why does BB use seem paradoxical in HF?
they can cause drop in CO initially (bad).
over long term, have decreased mortality do to
what all is decreased by BBs in HF?
BBs stop tachycardia caused from what in HF
when should BB's not be used for HF
list two vasodilators used in afterload reduction
what is in BiDil
hydralazine and ISDN
name a synthetic brain natriuretic peptide?
what is it's MOA
MOA = vasodilation by binds to GC receptor on vascular smooth muscle
what is brain naturetic peptide
a marker of HF
what does nesiritide do by binding to GC receptor?
increase cGMP leading to relaxation
also gives diuresis