HTN3 Flashcards Preview

Pharmacology II > HTN3 > Flashcards

Flashcards in HTN3 Deck (17)
Loading flashcards...
1

what ACE-I has a sulfonamide derivative, and should be avoided in pt's with sulfa allergies?

captopril

2

what is the half life of captopril

2 hours (BID-TID)

3

what is the IV formulated ACE-I

enalaprilat

4

where are the oral prodrug ACE-I's metabolized to active form?

in liver

5

what are the adverse effects of ACE-I's

Hypotension
Acute Kidney Injury
Dry Cough
Angioedema

6

how do ACE-I's cause AKI?

cause vasodilation of efferent arteriole, decreasing GFR

7

where in kidney does Angio II cause constriction

both afferent and efferent (ACEI's dilate only efferent)

8

what causes the dry cough with ACE-I's

increased bradykinin

9

what irritating endogenous substances are increased by ACE-I's

increase bradykinan
increase substance P
increase prostaglandins

10

ARB's have what type of binding to AT1 receptors

selective binding with high affinity (much higher than Angio II)

11

what ARB has the highest affinity for AT1 receptors?
which has the lowest?

highest affinity = irbesartan and olmesartan
lowest affinity = losartan

12

which ARB's are prodrugs

candesartan and olmesartan

13

where are pro-drugs hydrolyzed?

in GI tract

14

what ARB's are eliminated hepatically (don't use in pt's with liver disease)?

Telmisartan and Valsartan

15

what else are ARB's used for other than HTN?
which ARB's are best for which conditions?

DM nephropathy (irbesartan and losartan)
stroke prophylaxis (losartan)
HF (valsartan)

16

which of the following is an effect of activating RAAS?
A. increased NE reuptake
B. Increased ADH release
C. Renal vasoconstriction
D. Decreased SNS discharge

C. Renal vasoconstriction

17

which of the following antiHTN agents lowers BP by decreasing intravascular volume
A. Hydrochlorothiazide
B. Lisinopril
C. Aliskiren
D. Losartan

A. Hydrochlorothiazide