immunity Flashcards

(44 cards)

1
Q

What is virulence?

A

Virulence is the degree or severity of pathogenicity of a microorganism, indicating how harmful or aggressive it is in causing disease.

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2
Q

What is spread through direct contact?

A

Spread through direct contact involves physical contact between an infected individual and a susceptible host, such as skin-to-skin contact, touching, kissing, or sexual intercourse.

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3
Q

What is spread through indirect contact?

A

Spread through indirect contact occurs when an infectious agent is spread from a reservoir to a host through an intermediary, rather than directly from person to person.

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4
Q

What is spread through droplet?

A

Spread through droplet occurs when an infected person coughs, sneezes, or talks, releasing respiratory droplets that can travel short distances (less than 1 m).

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5
Q

What is spread through airborne?

A

Spread through airborne refers to the spread of pathogens through the air via tiny droplets or particles that can be inhaled (greater than 1 m).

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6
Q

What is spread through vehicle?

A

Spread through vehicle occurs when pathogens are spread through contaminated objects (fomites), food, water, or other vehicles.

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7
Q

What is spread through vector?

A

Spread through vector involves the transmission of pathogens by insects or other animals (vectors) that carry the pathogen and transmit it to a susceptible host.

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8
Q

What is a portal of entry?

A

The portal of entry is the route by which a pathogenic microorganism infects the host.

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9
Q

What is susceptibility?

A

Susceptibility is an increased vulnerability or tendency for an individual to develop a particular disease or condition.

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10
Q

What is an opportunistic infection?

A

Opportunistic infections are diseases that occur more frequently and severely in individuals with weakened immune systems.

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11
Q

What is a community acquired infection?

A

A community acquired infection is an infection contracted outside of a healthcare setting, meaning it’s not acquired within a hospital or other medical facility.

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12
Q

What is a nosocomial infection?

A

A nosocomial infection is an infection that occurs as a consequence of being in the hospital.

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13
Q

What does aerobic mean?

A

Aerobic refers to organisms that require oxygen to survive and thrive.

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14
Q

What does anaerobic mean?

A

Anaerobic refers to organisms that either cannot tolerate oxygen or thrive in its absence.

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15
Q

What are exotoxins?

A

Exotoxins are toxic peptides mostly secreted by Gram-positive bacteria; they are immunogenic and elicit the production of antibodies called antitoxins.

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16
Q

What are endotoxins?

A

Endotoxins are lipopolysaccharides (LPS) that are part of the outer membrane of Gram-negative bacteria; they are released during growth, lysis, or destruction (death).

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17
Q

What is sepsis?

A

Sepsis is a serious medical condition caused by an overwhelming immune response to infection, which can lead to death.

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18
Q

What is a bacterial infection?

A

A bacterial infection occurs when harmful bacteria invade the body, multiply, and cause illness.

19
Q

What is a viral infection?

A

A viral infection occurs when a virus invades a host cell and changes reproduction; these are self-limiting infections and cannot be treated with antibiotics.

20
Q

What is the difference between viral infection and bacterial infection?

A

Bacterial infections are caused by bacteria, which are single-celled organisms that can reproduce on their own and can be treated with antibiotics. Viral infections are caused by viruses, which are non-living entities that need to infect a host cell to reproduce and cannot be treated with antibiotics.

21
Q

What is a fungal infection?

A

A fungal infection involves large thick-walled organisms, often opportunistic, where decreased WBC promotes fungal infections. Candida albicans is the most common.

22
Q

What is a parasitic infection?

A

A parasitic infection occurs when a parasite, an organism that lives on or inside a host, infects the host and causes harm. These infections are typically caused by protozoa (worms), vector transmission (mosquitoes), and vehicle transmission (soil, food).

23
Q

What is innate immunity?

A

Innate immunity is the body’s initial, rapid, and general defense against pathogens and foreign substances, present at birth.

24
Q

What is adaptive immunity?

A

Adaptive immunity is not present at birth; it is created in response to exposure to a foreign substance. Once activated against a specific type of antigen, the immunity remains throughout life.

25
What is active immunity?
Active immunity is a type of immunity where your body's immune system is directly involved in creating antibodies to protect against a specific pathogen; it is long-lasting and can provide decades of protection.
26
What is passive immunity?
Passive immunity involves exposing the body to antigens through naturally acquiring the virus/bacterium or through vaccines to stimulate the body to produce antibodies.
27
What is acquired immunity?
Acquired immunity results from exposure to a pathogen via infection, vaccine, medicine, or maternal antibodies.
28
What are examples of innate immunity?
Examples of innate immunity include skin, hair, mucous membranes, cilia, saliva, phagocytes, inflammation, and fever.
29
What is natural immunity?
Natural immunity is immunity gained via previous infection or maternal antibodies.
30
What is artificial immunity?
Artificial immunity is protection against infectious diseases that is acquired through deliberate actions, such as vaccinations or the administration of antibodies.
31
What is a live attenuated vaccine?
A live attenuated vaccine is a weakened virus or bacterium that produces protective antibodies against a specific pathogen without causing the potentially life-threatening disease. An example is the MMR vaccine (measles, mumps, rubella).
32
What is an inactivated vaccine?
An inactivated vaccine consists of killed or extracts of bacterial or viral antigens; the vaccine is grown in culture media and then exposed to heat or chemicals to inactivate it.
33
What is a bacterial toxin vaccine (toxoid)?
A bacterial toxin vaccine (toxoid) is used for bacterial diseases that damage the body by secreting chemicals; the toxin is deactivated and then injected to create immunity.
34
What is immunodeficiency?
Immunodeficiency is the failure of the immune or inflammatory response to function normally, resulting in increased susceptibility to infections.
35
What is primary immunodeficiency?
Primary immunodeficiency is caused by a genetic defect.
36
What is secondary immunodeficiency?
Secondary immunodeficiency is caused by another condition, such as cancer, infection, or aging.
37
What is DiGeorge Syndrome?
DiGeorge Syndrome is characterized by a small part of chromosome 22 missing, leading to poor development of several body systems, phenotypic variability, unusual facial features, heart defects, thymus gland abnormalities, autoimmunity, and parathyroid gland abnormalities.
38
What are the stages of AIDS infection?
The stages of AIDS infection are: 1. Acute (massive replication, flu-like symptoms, 1-2 weeks after infection), 2. Asymptomatic (asymptomatic but virus proliferating in lymph nodes, lasting 10-12 years or longer), 3. Symptomatic (T-cells fall <200 cells per cubic millimeter of blood, late phase), 4. Advanced (T-cells fall <50 cells per cubic millimeter, high risk for opportunistic infections & malignancies).
39
What is hypersensitivity?
Hypersensitivity is an excessive or inappropriate response to an antigen resulting in damage to the host.
40
What is Type 1 hypersensitivity?
Type 1 hypersensitivity is an allergy/anaphylaxis that is IgE mediated with a quick onset, for example, a bee sting.
41
What is Type 2 hypersensitivity?
Type 2 hypersensitivity is cytotoxic, where IgG or IgM bind to cell receptors causing cell death, with a response time of 5-8 hours, for example, blood transfusions.
42
What is Type 3 hypersensitivity?
Type 3 hypersensitivity is immune complex mediated, where IgG or IgM bind to antigens forming complexes that are deposited into various tissues and destroy them, with a response time of 2-8 hours, for example, gluten allergy.
43
What is Type 4 hypersensitivity?
Type 4 hypersensitivity is delayed and cell-mediated, involving T-cells that produce lymphokines activating macrophages to attach to targets and release enzymes causing tissue destruction, for example, poison ivy.
44
What does ICED stand for in hypersensitivity?
ICED stands for I - Immediate (Type I), C - Cytotoxic (Type II), E - Immune complex (Type III), and D - Delayed (Type IV).