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Flashcards in Kaplan- Neuro 2 Deck (50)
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1

tricyclic antidepressants act on what receptor and what effect does this have on cAMP

TCA's antagonize D2 receptors leading to increased cAMP
(normal D2 receptor activity downregulates cAMP)

2

what part of the brainstem controls vertical eye movements and eyelid elevation (hint: this is why it is spared in locked-in syndrome)

rostral midbrain (rostral interstitial nucleus of MLF and interstitial nucleus of Cajal)

3

what are intracytoplasmic eosinophilic inclusions in neurons called

Lewy bodies

4

what are Pick bodies

round intracytoplasmic bodies that contain altered tau, ubiquitin and neurofilament

5

what do Lewy bodies contain

alpha-synuclein or ubiquitin

6

disruption of what brainstem structure will cause extrapyramidal symptoms

substantia nigra

7

what hormone levels should you make sure to check in a patient on lithium?

TSH (Lithium causes decreased TSH and thereby decreased thyroid hormones)

8

name the two streams of higher-order visual processing

dorsal pathway (parieto-occipital association cortex) (hair=where) relays visiospatial information

ventral pathway (temporo-occipital association cortex) (gut=what) relays information about colors, faces, symbols

9

what is the most common cause of ring-enhancing lesions in HIV patients

toxoplasmosis

10

what does CNS toxoplasmosis present like and what is seen on histology

CNS toxoplasmosis presents as AMS, seizures, or focal neurologic deficits;

on histology: necrotic, hemorrhagic lesions with round encysted bradyzoites (inactive) or crescent-shaped tachyzoites

11

central necrosis surrounded by granulation tissue and gliosis suggests what kind of infection?

bacterial abscess

12

what nerve provides sensation for the anatomical snuffbox

radial nerve

13

a patient with acute onset right homonomous hemianopia and intact visual acuity most likely has an infarct in which vessel

left PCA (macular sparing suggests the lesion is in the occipital lobe rather than one of the nerve tracts)

14

what vision defect does occlusion of the ophthalmic artery cause

monocular blindness

15

what is the most common cause of viral encephalitis in the U.S. and what region of the brain does it most commonly affect

HSV-1;
temporal lobe

16

what are the preferred benzos (name 3) for a patient with liver disease (i.e. alcoholics) and why are they preferred

"LOT" lorazepam, oxazepam and temazepam
better for patients with unhealthy livers because their metabolism is phase II rather than phase I, which starts to fail in liver disease; they also have less active metabolites

17

a central scotoma is likely due to a lesion where

the macula

18

what is the visual toxicity of ethambutol

optic neuropathy

19

a decline in cognitive function and gait as well as hypertonicity and dysarthria and abnormal EEG waves, all of which develop over the course of several months would likely involve what pathognomonic finding on autopsy

spongiform change in gray matter (CJD)
-rapidly progressing dementia with abnormal EEG findings suggests CJD

20

what nerve provides sensory innervation to the mucosa above the vocal cords?
below the vocal cords?

the internal branch of the superior laryngeal nerve supplies the mucosa above the vocal cords while the recurrent laryngeal nerve supplies the mucosa below the vocal cords

21

what is Werdnig-Hoffman disease and what part of the nervous system does it affect

spinal muscle atrophy due to perinatal programmed cell death that continues postnatally
anterior horn is affected

22

neuons of the spinal cord are myelinated by what kind of cell

oligodendrocytes, NOT Schwann cells (even though it's not the brain the spinal cord is still CNS)

23

which drugs tend to predispose to or cause acute angle glaucoma

anticholingergics and drugs with anticholinergic effects like amitryptiline, topiramate, cyclobenzaprine,

24

what are some key signs and symptoms of acute angle glaucoma

headache, seeing halos around lights, nausea/ vomiting, severe ocular pain, corneal edema and high IOP

25

what is the name of the condition in which a patient cannot recognize faces
and what kind of lesion produces this deficit

prosopagnosia; caused by bilateral lesion of the visual association cortex

26

what is anosognosia and what lesion produces this condition

a lack of awareness or understanding the one is suffering from a condition; usually caused by large lesion of nondominant parietal lobe producing lack of awareness of sensory or motor deficits

27

what serum marker can be used to test for myelomeningocele (either in maternal serum or amniotic fluid)

alfa-fetoprotein

28

name all of the ventricles of the brain and their origins

lateral ventricles (telencephalon), third ventricle (diencephalon), cerebral aqueduct (mesencephalon), upper half of 4th ventricle (metencephalon), lower half of 4th ventricle (myelencephalon)

29

what is albuminocytologic dissociation and what disease is it characteristic for

albuminocytologic dissociation is when there is an increase in CSF protein, but no increase in CSF cell count; characteristic of Guillan Barre syndrome (an autoimmune demyelinating disorder that causes ascending polyneuropathy, usually following GI or upper respiratory infection. It spontaneously resolves.)

30

Flexner-Wintersteiner rosettes (cuboidal-to-columnar cells surrounding a central lumen) found in a tumor of a child's eye suggests what disease and what chromosome association

retinoblastoma; chromosome 13