Lecture 25: Bordetella and Camplyobacter Flashcards

(46 cards)

1
Q

Kennel cough is a multifactorial disease that includes __ and ___

A
  1. Stress
  2. Infection with B. Bronchiseptica
  3. Canine pneumovirus
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2
Q

Bordetella is an extra cellular commensal in ___ of mammals and birds

A

Upper respiratory tract

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3
Q

Bordetella is a ___pathogen

A

Opportunistic

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4
Q

Bordetella is a gram ___, strictly ___

A

Negative, aerobic

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5
Q

Bordetella is catalase and oxidase ___

A

Positive

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6
Q

Bordetella has tropism for ___epithelium

A

Ciliated respiratory epithelium

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7
Q

How is Bordetella transmitted

A

Aerosol

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8
Q

What are the 3 virulence factor toxins associated with Bordetella

A
  1. Tracheal cytotoxin
  2. Dermonecrotic toxin
  3. Osteotoxin
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9
Q

What does tracheal cytotoxin do

A

Inhibits movement of cilia and tracheobronchial clearance. Can kill ciliated cells

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10
Q

What does dermonecrotic toxin do

A

Induces dermal necrosis and interferes with differentiation of osteoblasts leading to turbinate atrophy

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11
Q

What does osteotoxin do

A

Kills osteoblasts

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12
Q

What does B. Bronchiseptica cause in pigs

A

Atrophic rhinitis- turbinate hypoplasia

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13
Q

Bordetella Bronchiseptica causes atrophic rhinitis in pigs with co-infection with ___

A

P. Multocida

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14
Q

What disease does B. Bronchiseptica cause in dogs

A

Canine infectious tracheobronchitis

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15
Q

What does B. Avium cause in turkeys

A

Coryza

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16
Q

What are the clinical signs of kennel cough/ canine infectious tracheobronchitis

A

Coughing, retching, mild serous oculonasal discharge

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17
Q

What are the symptoms of Turkey coryza

A
  1. Beak breathing
  2. Sneezing
  3. Tracheal collapse
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18
Q

Turkey coryza predisposes birds to ___

A

Secondary infections- E. Coli

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19
Q

How do you dx Bordetella

A

Culture/ PCR of
1. Tracheal fluid
2. Sinus exudate

20
Q

How do you tx and prevent Bordetella Bronchiseptica in dogs

A
  1. Isolate and monitor for 2 weeks then try amoxicillin
  2. Vaccinate
21
Q

What can you add to poultry’s water to increase hygiene measures against Bordetella

22
Q

Antimicrobials are infective against what Bordetella infection

A

Turkey coryza/ B. Avium

23
Q

Where is camplyobacter found

A

Intestinal and genital tracts

24
Q

Camplyobacter causes ___ or ___

A

Diarrhea or abortion

25
What does C. Fetus subspecies venerealis cause and in who
Bovine reproduction tract—abortions, infertility
26
What does C. Fetus subspecies fetus cause and in who
GI tract of ruminants (especially sheep)— abortions
27
What does C. Jejuni cause and in who
GI of most species- abortions and enteritis
28
Outbreaks of Venereal disease: C. Fetus, C. Venerealis, and C. Jejuni are commonly where
Western states
29
What Camplyobacter causes diarrheal disease
C. Jejuni
30
Which Camplyobacter is a reportable disease
C. Jejuni
31
What are the virulence factors associated with Camplyobacter
1. Microcapsule 2. S layer
32
What does the micro capsule do
Reduces susceptibility to complement and phagocytosis
33
What does the S layer do
Immune evasion- has 8 variants
34
What are the clinical manifestations for bovine genital camplyobacteriosis
1. Temporary infertility 2. Abortion
35
___are asymptomatically infected carriers for C. Venerealis
Bulls
36
1/3 of cows affected with C. Venerealis carry disease long term, what causes the persistent infection
S layer- immune evasion
37
Persistent infection with C. Venerealis can cause __ if bacteria migrate to ___
Permanent infertility, oviducts (salpingitis)
38
What are the clinical manifestations of ovine genital camplyobacteriosis
1. Abortion in ewes 2. Necrotic placentitis
39
What are the clinical manifestations of canine intestinal camplyobacteriosis
1. Most are subclinical 2. Enteritis in puppies < 6m months
40
What Camplyobacter can cause Avium vibrionic hepatitis- spotty or necrotic liver
C. Jejuni
41
How do you dx camplyobacter spp
1. Vaginal flush with LRS 2. PCR 3. Culture
42
The culture for Camplyobacter requires __conditions
microaerophilic
43
What agar is selective for C. Jejuni
Skirrow agar
44
What is the treatment/ prevention for C. Fetus
1. Therapeutic vaccination 2. Isolate ewes 3. Chlortetracycline
45
What is treatment/ prevention for c. Venerealis
1. Dihydrostreptomycin 2. Pre/post breeding vaccination
46
What is tx/ prevention for C. Jejuni
1. Dihydrostreptomycin 2. Fluids and antibiotics for dehydrated puppies