Lipid metabolism

Question 1

receptors for chylomicron remnants

Answer 1

ApoE specific

Question 2

VLDL remnant maybe converted into

Answer 2

LDL

Question 3

chylomicron remnants are CATABOLIZED where

Answer 3

liver

Question 4

elevated plasma level projects against artherotherosclerosis

Answer 4

HDL

Question 5

cholesterol is transported from liver to extrahepatic tissues

Answer 5

LDL

Question 6

triglycerides are transported from liver to extrahepatic tissues

Answer 6

VLDL

Question 7

nascent chylomicron receives apolipoproteins C& E from

Answer 7

HDL

Question 8

apolipoprotein B-100 is present in

Answer 8

VLDL&LDL

Question 9

apolipoprotein B-48 is present in

Answer 9

chylomicrons

Question 10

familial hypercholesterolemia is associated with

Answer 10

increased LDL concentration

Question 11

conversion of fatty acyl-CoA derivative having 2 more carbon atoms involves as acetyl donor

Answer 11

Malonyl-CoA

Question 12

the rate limiting step of cholesterol biosynthesis is

Answer 12

HMG CoA reductase

Question 13

compound normally used to conjugate bile acids is

Answer 13

glycine

Question 14

B-oxidation of fatty acid chain produces

Answer 14

propionyl CoA

Question 15

chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular factions of the cell

Answer 15

microrosomes

Question 16

LCAT is

Answer 16

lecithin cholesterol acyl transferase

Question 17

the protein which is infact a multifunctional enzyme complex in higher organism is

Answer 17

fatty acid synthesis

Question 18

class of lipoproteins having a beneficial effect in artherosclerosis is

Answer 18

HDL

Question 19

the major source of cholesterol in arterial smooth muscle cells is from

Answer 19

LDL

Question 20

long chain fatty acyl CoA esters are transported across the mitochondria membrane by

Answer 20

carnitine

Question 21

the acetyl CoA formed on B-oxidation of all chain fatty acids is metabolized under normal circumstances to

Answer 21

CO2 and water

Question 22

in B-oxidation of fatty acids, what are utilized as coenzymes

Answer 22

FAD & NAD

Question 23

the most important sources of reducing equivalents for FA synthesis in the liver is

Answer 23

HMP-shunt

Question 24

as a result of each oxidation a long chain fatty acid is cleaved to give

Answer 24

an acid with Z-carbon less & acetyl CoA

Question 25

committed step in the biosynthesis of cholesterol from acetyl CoA is

Answer 25

formation of mevalinate from HMG CoA

Question 26

Acyl carrier protein is involved in the synthesis of

Answer 26

fatty acid outside the mitochondria

Question 27

ligated triacyglycerols are emulsified in the intestine by

Answer 27

bile salts

Question 28

the key enzyme in the regulation of fatty acid synthesis is

Answer 28

Acetyl-CoA carboxylase

Question 29

in the intestine, the dietary fat are hydrolized by

Answer 29

pancreatic lipase

Question 30

chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular fractions of the cell

Answer 30

microsomes

Question 31

B-oxidation of odd-carbon fatty acid chain produces

Answer 31

propionyl CoA

Question 32

long chain fatty acids enters mitochondria by

Answer 32

combing with carrier carnite

Question 33

HMG-CoA reductase is rate limiting enzyme of

Answer 33

cholesterol synthesis

Question 34

ketone bodies is synthesized from

Answer 34

Acetyl-Coa

Question 35

during starvation ketone bodies are synthesized in

Answer 35

Liver

Question 36

low carb diet with bad breath is due to

Answer 36

increased beta oxidization due to increased activity of hormone sensitive lipase with subsequent increased in ketone bodies in plasma

Question 37

the reducing equivalents necessary for fatty acid synthesis are produced during the conversion of

Answer 37

glucose-6-phosphate to ribose-5-phosphate

Question 38

TRUE of fatty acid synthase enzyme complex

Answer 38

The monomers are arranged in a head to tail configuration

Question 39

The phosphopanthetheine side chain is part of which sub-unit of fatty acid synthase enzyme complex

Answer 39

acyl carrier protein

Question 40

The committed step for the Beta-oxidation of FAs is inhibited by increased concentration of:

Answer 40

malonyl-coA

Question 41

The complete ATP yield of a saturated C16 FA is

Answer 41

106

Question 42

Condition that accelerates ketogenesis

Answer 42

decreased insulin/glucagon ratio

Question 43

Ketone bodies can be utilized by extra-hepatic tissues because of this enzyme

Answer 43

succinyl coA acetoacetate coA | SCAC

Question 44

This disease results from the accumulation of phytanic acid in the brain and kidneys of patients:

Answer 44

Refsums disease

Question 45

TRUE regarding apo-proteins

Answer 45

Apo D is present exclusively in HDL

Question 46

The concentration of this lipoprotein is inversely related to the incidence of coronary artery disease

Answer 46

HDL(2)

Question 47

Which receptors are actively involved in reverse cholesterol transport?

Answer 47

SR-B1

Question 48

The only part of an odd-chain fatty acid that is glucogenic is:

Answer 48

propionyl coA

Question 49

A patient with phenylketonuria has fair skin and blue eyes due to low levels of

Answer 49

tyrosine

Question 50

Thromboxane ⮞ stimulates _________ ⮞ vaso______

Answer 50

⮞ stimulates platelet aggregation | ⮞ vasoconstriction

Question 51

Prostacyclin ⮞ Inhibit _______ ⮞ vaso________

Answer 51

⮞ Inhibits platelet aggregation | ⮞ vasodilation