oncogenesis/signaling Flashcards
phosphorylation of PRB results to
cell cycle progression
provides the pivotal decisional checkpoint in the fate of the stimulus
BCL-2
Apoptotic pathway important after chemotherapy
p53-modified
the activity of this Cyclin complex results to chromosome condensation
cyclin D/cdk-1
true to molecular carcinogenesis
there is loss in function of oncogene
viral oncoprotein which facilitates degradation of p53
E6
true or false. APC in familial Adenomatous polyposis is an example of oncogene
True
true or false. gene amplification and formation of double minutes is an example
True
an adaptor protein which facilitates hydrolysis of GDP to GTP to form the active GTP-Rau complex in the RTX pathway
GEF
a second messenger which activates Kinase C Downstream in inositol phospholipid
DAG
which component of the RTK pathway functions as guanine exchange factor (GEF)
Sos
true or false. the endpoint of GPCR is increased concentration of second messengers
True
is the G protein involved in phospholipid signaling pathway Trimeric
yes
does Ras transiocates to the nucleus
noo
this enzyme activates production of IP3
Kinase C
a protein kinase which directly activates MAP kinase in the MAP kinase pathway
MEK
this links cAMP to transcription in the nucleus
CAPK
what activates the CYCLIN/CDK
VEGF
is G1/S cell cycle checkpoint regulated mainly by intracellular signals
yup
true or false. in knudson’s 2 hit hypothesis. the second hit is gross chromosomal loss
true
when RRB is inhibited, PRB is
in the phosphorylated state
provides the pivotal decisional checkpoint in the fate of the cell after a death stimulus
BCL-2
apoptotic pathway important after chemotherapy and radiation
p35-mediated
the activity of this cyclin complex results to chromosome condensation
cyclin B/cbk1
