March 16 test 1 Flashcards Preview

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Flashcards in March 16 test 1 Deck (22):
1

How is t 1/2 calculated and how long does it take for a drug to reach steady state?

Half life= 0.7 x Vd/CL

A drug infused at a constant rate takes 4-5 half-lives to reach steady state

2

How is maintenance dose calculated?

Cp x CL x dosage interval/F

Dosage interval--time between doses if NOT administered continuously

F= bioavailability, which = 1 if given IV

Cp= target plasma concentration at steady state

3

Staphylococcal scalded skin syndrome involves attachment of epidermolytic toxins A and B to what?

Desmoglein 1 --involves the desmosomes

4

Name the microtubule inhibitors and their MOA...

Paclitaxel--hyperstabilize microtubules

Vincristine and vinblastine--prevent microtubule assembly

Both develop resistance through B-tubulin mutation

5

What is the MOA of action of Dantrolene?

Prevents release of Ca++ from the SR of skeletal muscle by binding to the ryanodine receptor

6

What is the toxidrome of TCA overdose

3 C's

Coma
Convulsions
Cardiotoxicity

Tx: NaHCO3

7

Patient is on Haloperidol, a antipsychotic, and develops Tardive dyskinesia. They are switched to Clozapine, an atypical antipsychotic. What is the most common side effect with this drug?

Agranulocytosis--Must watch bone marrow CLOZely with CLOZapine

8

How is loading dose calculated?

Cp x Vd/F

Remember F is 1 if given IV

9

What type of reaction is seen with a PPD?

Type IV HSR--Sensitized lymphocytes encounter antigen

T-cell mediated response

10

What test is used to Dx latent or active TB and measures the interferon-g released from WBC?

Quantiferon-TB gold test

11

Struvite stones are caused by infection from what type of organism?

Urease producing microorganism
-Proteus, Klebsiella, Staph saprophyticus

12

Which inhaled anesthetic is associated with hepatotoxicity?

Halothane

Also the biggest propensity to cause malignant hyperthermia

13

Which inhaled anesthetic is associated with nephrotoxicity?

Methoxyflurane

14

Which inhaled anesthetic is associated with convulsions?

Enflurane

15

Which inhaled anesthetic is associated with airway irritation?

Desflurane

16

Name the selective serotonin reuptake inhibitors...

Fluoxetine
Paroxetine
Sertraline
Citalopram

FLashback PARalyze SEnior CITizens

17

What Chemo agents inhibit topoisomerase II?

Etoposide and teniposide

18

What chemo agents inhibit topoisomerase I?

Irinotecan and topotecan

19

Severe heart failure and renal dysfunction require what type of diuretic?

Loop diuretic -- furosemide

20

What diuretic is CI with severe HF due to the possibility of worsening the HF?

Mannitol

21

What is the mechanism of action of metronidazole?

Formation of intracellular toxic metabolites in bacteria

22

H. pylori infection is associated with development of what carcinoma?

MALToma -- low grade type of non-Hodgkin lymphoma