Flashcards in March 19 test 2 Deck (12):
What is the cause of hereditary spheocytosis?
Defect in proteins interacting with RBC membrane
Premature removal by the spleen--so tx is splenectomy
Pt presents with mucocutaneous bleeding and mild petechial hemorrhages with an isolated thrombocytopenia. What is the dz and what is causing it?
Immune thrombocytopenia--Anti-GpIIb/IIIa antibodies--splenic macrophage consumption of platelet-antibody complex
Commonly due to viral illness
What abnormal labs are seen with von Willebrand disease?
Increased PTT-- vWF acts to carry/protect factor VIII
Increased bleeding time
What leukemia is associated with down syndrome and has massive increase in lymphoblasts?
Has an acute onset
What is the cause of Patau syndrome?
Maternal nondisjunction --trisomy 13
What type of lymphoma is characterized by Reed-Sternberg cells?
Majority of non-Hodgkin lymphomas involve ____ cells?
What is associated with hyperhsegmented PMNs?
Vit B12 deficiency --pernicious anemia
Pt with a1 antitrypsin deficiency with cirrhosis will show what on biopsy?
Intracellular PAS + globules
Pt presents with hyperthyroid symptoms in an ovarian tumor composed of thyroid tissue. Dx?
What is the distinguishing feature of focal segmental glomerulosclerosis?
Large focal hyaline deposits on biopsy