March 22 Flashcards
(47 cards)
Disease that presents with diffuse muscle atrophy, hypotonia, fasciculations and decreased DTR–is due to destruction of the anterior horn cells of the spinal cord..
Werdnig-Hoffmann disease
What enzyme catalyzes the formation of a phosphodiester bond within a strand of dsDNA–Joins Okazaki fragments?
DNA ligase
What ocular muscle is innervated by CN VI?
Lateral Rectus
What ocular muscle is innervated by CN IV?
Superior Oblique
What ocular muscles are innervated by CN III?
Superior rectus
Medial rectus
Inferior rectus
Inferior oblique
What enzyme is deficient in Maple syrup urine disease?
a-ketoacid dehydrogenase–causes increase in a-ketoacids in the blood
- Isoleucine
- Leucine
- Valine
What NT is responsible for REM sleep?
Acetylcholine
Why is hypoglycemia seen with maple syrup urine disease?
Occurs secondary due to impaired gluconeogenesis
Congenital defect causing abdominal contents to enter the thorax is caused by failure of what to completely form?
Failure of Pleuroperitoneal folds/membrane to form
Urachal cyst or sinus if remnant of _____ and forms the ______ ligament?
AllaNtosis
MediaN umbilical ligament
What is used to confirm dx of Acromegaly?
Glucose tolerance test–give glucose and if GH is not suppressed–indicated excess GH that is unresponsive to negative feedback
Also–will have increased IGF-1 and may have pituitary mass on MRI
What NT is elevated with schizophrenia?
DA–in mesolimbic frontal system
What is the classic murmur for mitral stenosis?
Opening snap followed by a late diastolic rumble
What heart defect can cause hoarseness due to compression of the left laryngeal nerve?
Mitral valve stenosis –leading to LA hypertrophy—compression of left laryngeal nerve as it hooks around the aorta at the ligamentum arteriosum –Ortner syndrome
Positive skew distribution =
Asymmetry with longer tail on right–Mean > Median > mode
Negative skew distribution=
Asymmetry with longer tail on left–mean
Put these in order from fastest to slowest conduction velocity – atria, ventricles, AV node, purkinje
Purkinje > atria > ventricles > AV node
What type of Nephritic syndrome is present with SLE?
Diffuse proliferative GN –wire looping (Lupus)
What can prolong the infection time of nontypoidal Salmonella spp infection?
Tx with abx–but do tx typoid with abx
What nerve is effected causing wrist drop and what are the 2 clinical situations in which this can occur?
Radial nerve (C5-T1)–Midshaft fracture of the humerus and compression of the axilla
N-acethlcysteine is used in CF pts in order to…
Helps break up mucus plugs
A mutation in what causes the classical type of Ehlers-Danlos syndrome?
Type V collagen–joint and skin symptoms
A mutation in what causes the vascular type of Ehlers-Danlos syndrome?
Deficient type III collagen–vascular and organ rupture
What is 1st line therapy for HepB infection?
Tenofovir
