March 17 test 3 Flashcards Preview

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Flashcards in March 17 test 3 Deck (14)
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1
Q

What is the first line therapy for BPH and what is its MOA?

A

Finasteride–5a-reductase inhibitor–decreases the conversion of testosterone to DHT

2
Q

Methotrexate can cause myelosuppression which can be reverse with administration of what?

A

Leucovorin–Folinic acid a folic acid analog

3
Q

What thionamide is used for hyperthyroidism in pregnancy and blocks peripheral conversion of T4 to T3?

A

Propylthiouracil–PTU

4
Q

What is anti-histone antibody sensitive for?

A

Drug induce lupus –hydralazine and procainamide

5
Q

What is 1st line therapy for ulcerative colitis?

A

Sulfasalazine–A combination of sulfapyridine (Antibacterial) and 5-amniosalicylic acid (anti-inflammatory)

6
Q

What antibiotic can cause Cholestatic hepatitis causing jaundice?

A

Macrolides–especially erythromycin

7
Q

What anti epileptic drug can cause hepatotoxicity, weight gain and is contraindicated in pregnancy because it can cause neural tube defects?

A

Valproic acid

8
Q

What chemo agent is contraindicated with renal insufficiency due to its nephrotoxicity effect?

A

Cisplatin/Carboplatin –also have ototoxicity effect

9
Q

What 2 drugs at on the kidney to inhibit uric acid reabsorption in PCT?

A

Probenecid and sulfinpyrazone

10
Q

What is the most effective way to lower LDL cholesterol in a pt with multiple risk factors for CAD?

A

Statin and bile acid sequestering combination

11
Q

What condition is characterized by rigidity, myoglobinuria autonomic instability, hyperpyrexia and is caused by antipsychotics. What is the tx for it?

A

Neuroleptic malignant syndrome (NMS)

Tx: Dantrolene or D2 agonist–bromocriptine

12
Q

What is the MOA of Ondansetron?

A

5-HT3 antagonist–decreases vagal stimulation

13
Q

What is Lithium used for and what are the major side effects?

A

Bipolar disorder

Side effects:
LMNOP
-Lithium
-Movement
-Nephrogenic DI
-HypOthyroid
-Pregnancy problems--Ebseins anomaly--malformed tricuspid valve
14
Q

How is ‘redman’ syndrome avoided with vancomycin administration?

A

Slow infusion over 1-2 hours and pre-treatment with antihistamine