March 17 test 3 Flashcards Preview

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Flashcards in March 17 test 3 Deck (14):
1

What is the first line therapy for BPH and what is its MOA?

Finasteride--5a-reductase inhibitor--decreases the conversion of testosterone to DHT

2

Methotrexate can cause myelosuppression which can be reverse with administration of what?

Leucovorin--Folinic acid a folic acid analog

3

What thionamide is used for hyperthyroidism in pregnancy and blocks peripheral conversion of T4 to T3?

Propylthiouracil--PTU

4

What is anti-histone antibody sensitive for?

Drug induce lupus --hydralazine and procainamide

5

What is 1st line therapy for ulcerative colitis?

Sulfasalazine--A combination of sulfapyridine (Antibacterial) and 5-amniosalicylic acid (anti-inflammatory)

6

What antibiotic can cause Cholestatic hepatitis causing jaundice?

Macrolides--especially erythromycin

7

What anti epileptic drug can cause hepatotoxicity, weight gain and is contraindicated in pregnancy because it can cause neural tube defects?

Valproic acid

8

What chemo agent is contraindicated with renal insufficiency due to its nephrotoxicity effect?

Cisplatin/Carboplatin --also have ototoxicity effect

9

What 2 drugs at on the kidney to inhibit uric acid reabsorption in PCT?

Probenecid and sulfinpyrazone

10

What is the most effective way to lower LDL cholesterol in a pt with multiple risk factors for CAD?

Statin and bile acid sequestering combination

11

What condition is characterized by rigidity, myoglobinuria autonomic instability, hyperpyrexia and is caused by antipsychotics. What is the tx for it?

Neuroleptic malignant syndrome (NMS)

Tx: Dantrolene or D2 agonist--bromocriptine

12

What is the MOA of Ondansetron?

5-HT3 antagonist--decreases vagal stimulation

13

What is Lithium used for and what are the major side effects?

Bipolar disorder

Side effects:
LMNOP
-Lithium
-Movement
-Nephrogenic DI
-HypOthyroid
-Pregnancy problems--Ebseins anomaly--malformed tricuspid valve

14

How is 'redman' syndrome avoided with vancomycin administration?

Slow infusion over 1-2 hours and pre-treatment with antihistamine