Micro 2 Prions Flashcards Preview

Test 7 > Micro 2 Prions > Flashcards

Flashcards in Micro 2 Prions Deck (16):
1

Normal protein and gene

PrPc
PRNP

2

Histological Dx

Spongiform pattern with no inflammation

3

Most common CJD

Sporadic

4

fCJD inheritance

Autosomal dominance

5

PrP plaque stain color

Brown

6

Classic v. Variant CJD histopathology

Even spread v. Florid plaques (clumps)

7

vCJD changes

Most evident in BG & Thalamus
florid plaques
psychiatric -> cerebellar

8

vCJD inheritance

none LOL

9

CJD v vCJD on MRI

Pulvinar sign on vCJD

10

Kuru progression

Ataxia -> Dementia

11

vCJD progression

Psychiatric -> Ataxia -> Dementia (14 months)

12

CJD progression

Dementia/Ataxia (5 months)

13

Gerstmann-Straussler Scheinker Syndrome

Pronounced Cerebellar degeneration

14

Fatal Familial Insomnia

Insomnia first
D178N mutation

15

Myoclonus

sCJD

16

vCDJ allele

Methionine at codon 129