Pharm 12 Drug Abuse Flashcards Preview

Test 7 > Pharm 12 Drug Abuse > Flashcards

Flashcards in Pharm 12 Drug Abuse Deck (19):
1

Tolerance mechanism

Homeostatic adaptation

2

Tolerance is evidence of

Physical dependence

3

Tolerance does not imply

Addiction

4

DA reward circuit

VTA -> NAc -> Behavior

5

Opioids site of action

MOR -> inhibit GABA interneurons that are inhibiting DA neurons

6

Opioid mixed agonist Tx

-Buprenorphine-

7

Opioid withdrawal Tx

-Methadone- (no euphoria)
-Clonidine- (A2 agonist inhibits LC)

8

Benzodiazepine activation of NAc

Disinhibit DA via inhibiting GABA interneurons

9

Benzodiazepine OD Tx

Flumazenil

10

Long term compensation for stimulant use

Increase in DA excitability

11

Psychostimulant OD Tx

Sedatives
Anti-psychotics (SE - lower seizure threshold)

12

Stimulant vaccine

Cocaine antibodies

13

Nicotine activation of NAc

Excite glutamate neurons via nAChR

14

Psychedelic activation of NAc

Very little
No dependence

15

Hallucinogen MOA

5-HT2A agonist (LSD)
SRI (MDMA)

16

Hallucinogen Tx

Diazepam for bad trip
NOT antipsychotics

17

Dissociative MOA

NMDA glutamate blockade

18

Dissociative Tx

Antipsychotic if MILD
Avoid chlorpromazine (anticholinergic)

19

Cannabinoid activation of NAc

Decrease GABA release from interneuron