Pharm 13 Ethanol Flashcards Preview

Test 7 > Pharm 13 Ethanol > Flashcards

Flashcards in Pharm 13 Ethanol Deck (23):
1

Alcohol Metabolites:
1st
2nd

Acetaldehyde (toxic)
Acetate

2

Both alcohol metabolism steps generate

NADH (reducing equivalents)

3

Metabolism kinetics

Zero order (constant)

4

Alternate pathway

CYP450 (CYP2E1)
Reduces glutathione -> reduced antioxidants

5

NT effects

Stimulate GABA (motor)
Inhibite Glutamate (cognitive)
Increase DA in NAc

6

Ethanol effect on fat

Spare utilization of FA -> Lipid deposition

7

Ethanol effect on glucose

Inhibit gluconeogenesis -> Hypoglycemia

8

Effect on corticosteroids

Increase

9

Fetal Alcohol Syndrome hot word

Thin upper lip

10

EtOH interaction with Nitroglycerin

Enhance hypotension

11

Drugs competing with CYP450 for clearance

Aspirin
Phenytoin (prolonges Na channel inactivation)

12

Drug inhibiting stomach ADH

Aspirin

13

Drugs inhibiting ALDH -> Flush

Metronidazole
Cephalosporins
Disulfiram

14

Effect from chronic upregulation of CYP2E1

Acetaminophen hepatotoxic byproducts

15

Alcohol withdrawal Tx

Benzodiazepines
Maybe BB or Clonidine for tachycardia

16

Hangover word

Veisalgia

17

Irreversible ALDH inhibitor

-Disulfuram-

18

Oral opioid antagonist

-Naltrexone-

19

NMDA interactor
(Increase abstinence, no effect on craving)

-Acamprosate-

20

3 off label drugs

Topiramate (GABA facilitator)
Tiapride (Antipsychotic)
Ondansetron (Antiemetic)

21

Methanol end product

Formic acid

22

Ethylene Glycol end product

Oxalic acid

23

Ethylene Glycol Tx

-Fomepizole-
(ADH inhibitor)