Pharm 9 Headache Flashcards Preview

Test 7 > Pharm 9 Headache > Flashcards

Flashcards in Pharm 9 Headache Deck (30):
1

Prolongued use of acute Tx

Leads to daily headache that doesn't respond to preventative therapy

2

NSAIDs

For mild episodes without nausea or need for bed rest

3

Combination analgesics

Aspirin, acetaminophen, cafeine

4

-Metoclopramide-

Antiemetic
5HT agonist
D2 antagonist

5

-Butorphanol-

Opioid nasal spray

6

Opioid + NSAID

-Tramadol & Acetaminophen-
Be wary of addiction potential

7

-Dexamethasone-

Corticosteroid
Reduces recurrence, not acute pain

8

-Reserpine-

Triggers migraine

9

-Sumatriptan-

5HT agonist

10

Ergot alkaloids

Fungal derivative
Vasoconstrictors
Nonspecific 5HT & Alpha agonists

11

Ergot CI

Triptans

12

Ergotamine SE

Severe vasoconstriction
Nausea & vomiting

13

Dihydroergotamine

Safer than Ergotamine

14

-Triptans-
MOA

5HT-1 agonists

15

Triptans with longer half life

Naratriptan
Frovatriptan

16

Triptan Contraindications

Preexisting HTN
Ergotamine
MAOI

17

Indication for preventative therapy

>2 bad headaches per month

18

-Valproate-
Indication
MOA

Prophylaxis
Anticonvulsant (Enhance GABA)

19

SSRIs

Not effective at preventing migrane

20

-Amitriptyline-

TCA
Block NE & 5HT reuptake

21

-Nortriptyline-

TCA
Block NE & 5HT reuptake

22

-Propranolol & Timolol-

B Blockers
Prophylaxis

23

-Verapamil-

Calcium Channel Blocker
Low efficacy for migraine, can't use with BB, Ergot, Triptan

24

-Methylsergide-

5HT2 antagonist
High efficacy for migraine Tx

25

-Botox-

Inject across head and neck for chronic migraine

26

-Naproxen Sodium-

NSAID
Short term prevention
Abort acute migraine

27

-Flurbiprofen-

NSAID
Short term prevention
Abort acute migraine

28

Caffeine

Increase NE & DA release
Vasoconstriction
Increase NSAID effectiveness

29

-Amitriptyline-

NSAID for Tension headache preventative therapy

30

Cluster headache Tx

O2 (vasoconstriction)
Intranasal lidocaine