Neuro E Movement Disorders Flashcards Preview

Test 7 > Neuro E Movement Disorders > Flashcards

Flashcards in Neuro E Movement Disorders Deck (30):
1

Rate limiting step in DA creation

Tyrosine hydroxylase (Tyrosine -> L-Dopa)
(1st step)

2

Rate limiting step in Parkinsons patient who you give L-Dopa

Dopa decarboxylase (L-Dopa -> Dopamine)

3

Chorea

-Dance
-Irregular

4

Sydenham's Chorea

Secondary to Group A Strep infection
-Shows with carditis, arthritis, rheumatic fever

5

Sydenham's Chorea Dx
Tx

Antistreptolysin antibody titer

Antibacterial and Antipsychotics

6

Huntington's Disease Triad
Anatomy

Chorea, Dementia, Psychiatric D/O

Destruction of Caudate and Putamen

7

Huntington's genetics

Chromosome 4 CAG repeat (>36)

Anticipation

8

Huntington's Tx

Tetrabenazine, Antipsychotics (only for chorea)

9

Hemiballismus - Anatomy
-Features
-Tx

-Lesion to contralateral subthalamic nucleus
-Unilateral wild limb jerking
-Antipsychotics

10

Intention Tremor drug causes

Alcohol, Anticonvulsants, Sedatives
(Cerebellum)

11

Postural (physiologic) Tremor drug causes

Physiologic causes

Lithium, Bronchodilators, Theophylline, Alcohol withdrawal

Hyperthyroidism, Anxiety

12

Spasticity v Rigidity problem location

Corticospinal v Basal Ganglia

13

Cogwheel rigidity

Parkinsonian

Tremor on top of Rigidity (BG)

14

Lewy Body protein

Alpha Synuclein

15

Parkinsons Tx

symptom based (bradykinesia)
-L-Dopa - Carbodopa (peripheral blocker)
-Anticholinergics
-Amantadine (antiviral)
MAO B inhibitor

16

NT from Frontal Lobe to Basal Ganglia (excitatory)

Acetylcholine

17

Parkinsons drug Tx theory

Give direct agents first, DA later. This delays "on/off" phenomenon

18

Direct Dopamine Agonists

Ropinirole
Pramipexole

19

Anticholinergics

Benztropine
Trihexyphenidyl

20

Surgical Tx of Parkinsons

DBS of Thalamus and Globus Pallidus

21

Restless Leg Syndrome drug Tx

DA agonist
Iron supplementation
Sedatives

22

RLS anatomy

Reticular Formation

23

Parkinsonism drug causes

Antipsychotics

24

"Parkinson's Plus" Syndrome

Parkinsons-like, but different clinical presentation and different L-Dopa response

25

Parkinson's Plus Syndromes (3)

-Progressive Supranuclear Palsy
-Multiple System Atrophy
-Diffuse Lewy Body Dementia

26

Dystonia

Slow twisting of body, fixed posturing

27

Torticollis

Cervical dystonia, often with arm held in hyperpronated position

28

Blepharospasm

Forced closure of eyelids for period of time, often with facial grimacing

29

Writer's cramp

Dystonic posture of hand & forearm when pen is held

30

Wilson's Disease drug Tx

Penicillamine (copper chelator)