Pharm 7 Anti-Parkinsons Flashcards Preview

Test 7 > Pharm 7 Anti-Parkinsons > Flashcards

Flashcards in Pharm 7 Anti-Parkinsons Deck (28):
1

Amount of neurons lost needed for for Parkinson's symptoms

60%

2

Parkinson's effect on STN

Increased activation of STN

3

-Reserpine-

Deplete dopamine

4

Brain area of Dopamine depletion

Striatum (Putamen, Globus Pallidus)

5

-Carbidopa-

Inhibit peripheral decarboxylation of DA

6

L-Dopa side effects

"on-off" freezing
Peak dose grimacing & dyskinesia
Behavioral SE
Dementia

7

-Bromocriptine-
Indication
MOA

L-DOPA adjunct
D2 agonist, D1 antagonist

8

-Bromocriptine-
Metabolism

Liver
4-6h half life (short)

9

-Pergolide-
MOA
SE

D1 and D2 agonist
Heart valve regurgitation (withdrawn)

10

-Pramipexole-
Indication
MOA

Early mono-therapy
Also L-DOPA adjunct (reduce on-off effects)

D2 agonist

11

-Pramipexole-
Metabolism

Kidney
8-14h half life

12

-Ropinirole-
Indication
MOA

Early mono-therapy
L-DOPA adjunct

D2 agonist

13

-Ropinirole-
Metabolism

Liver
3-4h half life (short)

14

-Selegiline-
Indication
MOA

Early mono-therapy
L-DOPA adjunct
Improve cognitive functions

MAO-B inhibitor

15

-Selegiline-
Metabolism

Liver
1.5h half life (short)

16

-Selegiline-
Contraindications

TCA
SRI
(Serotonin syndrome)

17

-Tolcapone-
Indication
MOA

Late adjunct
Inhibit CNS & peripheral COMT

18

-Entacapone-
Indication
MOA

Late adjunct
Inhibit peripheral COMT

19

COMT inhibitor main use

Patients that develop "freezing"
Ameliorate peak dose dyskinesia

20

-Amantadine-
Indication
MOA

Early onset PD, heavy bradykinesia

Enhance DA levels
Anticholinergic
Anti-viral
NMDA antagonist

21

Drug eliciting orthostatic hypotension & cardiac arrhythmia SE

Bromocriptine

22

Drugs contraindicated with HTN

MAO B inhibitors

23

PD surgery

Deep Brain Stimulation of STN

24

Huntington's chorea Tx

Reserpine

25

Tourette's Tx

Neuroleptics (Haloperidol or pimozide)
Alpha 2a Agonists (Clonidine or guanfacine)
SSRIs (Fluoxetine)

26

Benign Essential Tremor Tx

Primidone (anti-convulsant)

27

Dystonia Tx

Botox

28

ALS Tx

Baclofen for spasticity