MODULE 6 PART 3: PROCESSING OF EXOGENOUS ANTIGEN (MHC CLASS II)

Question 1

(1) Exogenous Ag are taken into cells by _____.

Answer 1

endocytosis

Question 2

(2) The Ag is contained in an intracellular vesicle that then fuses with existing _____ or _____ vesicles.

Answer 2

endosomal or lysosomal

Question 3

(3) Degradative enzymes such as ____ are involved in the selective cutting of protein Ag.

Answer 3

cathepsins

Question 4

(4) ____ intersect with vesicles containing newly synthesized MHC class II molecules.

Answer 4

Peptides

Question 5

(5) MHC class II molecules are synthesized on _____ of the ____.

Answer 5

ribosomes of the ER

Question 6

(6) The chains associated in the ER with a molecule known as ____ chain.

Answer 6

invariant/II/CD74

Question 7

(7) ____ region with the groove of MHC class II prevents the binding of endogenous peptides found in ER.

Answer 7

II

Question 8

(8) II is degraded leaving a fragment known as ____ to the MHC II-groove.

Answer 8

CLIP (Class II-associated invariant chain)

Question 9

(9) In acid vesicles containing peptides, a molecule known as ____ facilitates exchange between MHC class II-clip complex and peptides.

Answer 9

HLA-DM

Question 10

(10) The complex then moves to the cell surface where it can interact with ____ expressing the appropriate receptor.

Answer 10

Helper T cell (CD4)