MODULE 6 PART 2: PROCESSING OF ENDOGENOUS ANTIGEN (MHC CLASS I)

Question 1

(1) Endogenous Ag (viral or parasitic in origin) are generally synthesized within the cell particularly in the _____ compartment.

Answer 1

cytosolic

Question 2

(2) Protein molecules generated from the endogenous Ag is linked to _____ and marked for destruction.

Answer 2

ubiquitin

Question 3

(3) Proteins present in cytosol are degraded by the _____.

Answer 3

proteasome

Question 4

(4) The resulting particles are internalized by the ___ channel in the endoplasmic reticulum, where they become associated with freshly synthesized MHC I molecules.

Answer 4

TAP

Question 5

(5) The MHC-I/peptide complexes enter the ______, where they are glycosylated and from there they enter in secreting vesicles, which fuse with the cell membrane.

Answer 5

golgi apparatus

Question 6

(6) In this way, the complexes become exposed to outside of the cell and allows contact with circulating _____ T cells.

Answer 6

cytotoxic