MODULE 5 PART 2.5: RECOVERY FROM INFLAMMATION

Question 1

When the invading organisms are destroyed, the tissue response should be switched from killing process to ____ process.

Answer 1

repair

Question 2

Macrophages begin to secrete ____ which inhibits the release of elastase and oxidants by TNF-stimulated neutrophils and inhibits the activity of elastase.

Answer 2

SLP1 (serine protease inhibitor)

Question 3

Neutrophils also secrete ______ that neutralize the TNF-a.

Answer 3

TNF receptor fragments

Question 4

The neutrophil and macrophage-derived ____ destroy chemotactic factors.

Answer 4

oxidants

Question 5

Since neutrophils are short-lived and usually die during inflammatory response, they tend to rupture and release ____ enzymes that could cause severe tissue damage.

Answer 5

lysosomal

Question 6

Severe tissue damage caused by lysosomal enzymes by neutrophils does not normally occur because as they undergo apoptosis, they are ?

Answer 6

phagocytosed by macrophages

Question 7

By releasing ____, macrophages attract and activate fibroblasts which migrate into the damaged and area and secrete collagen.

Answer 7

IL-1

Question 8

____ is gradually remolded over several weeks or months as the area returns to normal.

Answer 8

Collagen