MODULE 6 PART 1: INTRODUCTION TO MAJOR HISTOCOMPATIBILITY COMPLEX

Question 1

In order to trigger an acquired immune response, the antigen must be bound to an appropriate antigen-presenting receptor. These antigen-presenting receptors are called ?

Answer 1

Histocompatibility complex

Question 2

Antigen fragments can only trigger an immune response if they are bound to MHC molecules and termed as ?

Answer 2

MHC restriction

Question 3

Gene region that contains the specialized receptor glycoprotein for the antigen-processing and presentation

Answer 3

Major Histocompatibility Complex (MHC)

Question 4

MHC class I has highest concentration on ?

Answer 4

Lymphocytes and macrophages

Question 5

MHC Class I is found on surfaces of ?

Answer 5

Most nucleated cells of the body

Question 6

MHC Class I is not found on ____ RBC but are present on ____ RBC.

Answer 6

human; mouse

Question 7

This class of MHC displays what is going on inside the cell especially in the case of viral infection and peptides bound in MHC class I are presented to cytotoxic T cells.

Answer 7

MHC class I

Question 8

What are the different domains of MHC class I?

Answer 8

• Beta
• a1
• a2
• a3

Question 9

CD8 binds to what domain of MHC class I?

Answer 9

a3

Question 10

MHC class II is found on ?

Answer 10

Specialized antigen-presenting cells (macrophages, dendritic cells, and B cells)

Question 11

This class of MHC displays what is going on outside the cell especially in the case of bacterial infection and present exogenous antigens to helper T cells.

Answer 11

MHC class II

Question 12

What are the domains of MHC class II?

Answer 12

• a1
• a2
• b1
• b2

Question 13

CD4 binds to what domain of MHC class II?

Answer 13

B2

Question 14

This class of MHC code for proteins with many different functions - C2, C4, factor B

Answer 14

MHC class III