Module 9 4.Patho: Describe the Host Defense Against Pathogens (HINT: Table 6.1 in Power-Kean) and the manifestation of associated signs/symptoms of infection Flashcards
What is the level of defense provided by barriers in the human immune system?
First line of defense against infection and tissue injury.
What is the timing of defense for innate immunity in the human immune system?
- Immediate response to tissue injury or infection (inflammatory response).
What is the specificity of innate immunity in the human immune system?
- Broadly specific.
What are some cells involved in innate immunity in the human immune system?
- Mast cells, granulocytes (neutrophils, eosinophils, basophils), monocytes/macrophages, natural killer (NK) cells, platelets, and endothelial cells.
. Does innate immunity involve immunological memory?
- No memory is involved in innate immunity.
What are some active molecules in innate immunity in the human immune system?
- Complement, clotting factors, kinins, cytokines.
What is the level of defense provided by adaptive (acquired) immunity in the human immune system?
- Third line of defense, initiated when the innate immune system signals cells of adaptive immunity.
What is the timing of defense for adaptive immunity in the human immune system?
- There is a delay between primary exposure to antigen and the maximal response, but the response is immediate upon secondary exposure to the antigen.
What is the specificity of adaptive immunity in the human immune system?
- The response is very specific toward the “antigen.”
What are some cells involved in adaptive immunity in the human immune system?
- T cells, B cells, macrophages, and dendritic cells.
Does adaptive immunity involve immunological memory?
- Yes, adaptive immunity involves specific immunological memory by T and B cells.
What are some active molecules in adaptive immunity in the human immune system?
- Antibodies, complement, and cytokines.
