Module 9 Part 2 Pertussis

Question 1

What is the probable organism responsible for pertussis (whooping cough)?

Answer 1

Bordetella pertussis.

Question 2

What are the first-line antibiotics for treating pertussis in adults and children?

Answer 2

For Adults: Erythromycin (1-2 grams per day). For Children: Clarithromycin (15 mg/kg/day, divided BID) or Azithromycin (10 mg/kg on the first day, then 5 mg/kg/day x 4 days).

Question 3

When should chemoprophylaxis be provided for pertussis contacts?

Answer 3

All household contacts, regardless of age and immunization status, should be offered chemoprophylaxis. It is essential in infants < 1 year old or patients in the 3rd trimester of pregnancy residing with or having been in close contact with the index case.

Question 4

What is the duration of infectiousness in pertussis cases?

Answer 4

The patient is generally considered infectious until 3 weeks after the onset of cough (without therapy) or until 5 days after starting therapy.

Question 5

What is the preferred treatment for infants with pertussis?

Answer 5

Macrolides, especially azithromycin, are the preferred treatment for infants with pertussis. For children 2 months of age and older, an alternative to macrolides is TMP/SMX.