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Flashcards in M.O.D.Y Deck (15)
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1
Q

What does M.O.D.Y stand for?

A

Maturity onset diabetes of the young

=> Type 2-like Diabetes that comes on usually before the age of 25

2
Q

If M.O.D.Y is similar to Type 2 diabetes, do patients require insulin?

A

No

They are still capable of synthesising and releasing insulin

3
Q

What do the majority of genetic mutations in M.O.D.Y affect?

A

Glucokinase

Transcription Factors

4
Q

Patients with M.O.D.Y have a lower resting blood glucose than people without diabetes. TRUE/FALSE?

A

FALSE

they have a HIGHER resting blood glucose

5
Q

When do patients with Glucokinase mutations usually present?

A

Onset at birth

6
Q

What is the difference between hyperglycaemia in Glucokinase and Transcription factor mutations?

A

Glucokinase mutations = stable hyperglycaemia through life

Transcription Factor mutations = progressive hyperglycaemia

7
Q

How is a Glucokinase mutation M.O.D.Y treated?

A

Dietary measures

8
Q

Are complications common or rare in glucokinase mutation M.O.D.Y?

A

Rare

9
Q

When do Transcription Factor mutation M.O.D.Ys usually present?

A

Adolescence/young adult onset

10
Q

How are Transcription factor mutation M.O.D.Ys treated?

A

1/3 diet
1/3 oral hypoglycaemic agents
1/3 Insulin

11
Q

Are complications rare or common in Transcription factor mutation M.O.D.Y?

A

Common

12
Q

When does neonatal diabetes usually occur?

A

3-6 months after birth

13
Q

What are the two types of neonatal diabetes?

A

Transient (Resolves median 12 weeks - Stop insulin)

Permanent (Lifelong insulin)

14
Q

Briefly explain how sulphonylureas work

A

close K-ATP channel
Membrane depolarised
Calcium influx
Insulin secretion

15
Q

What is the main cause of neonatal diabetes?

A

Potassium (K-ATP) channel mutations