What does M.O.D.Y stand for?
Maturity onset diabetes of the young
=> Type 2-like Diabetes that comes on usually before the age of 25
If M.O.D.Y is similar to Type 2 diabetes, do patients require insulin?
No
They are still capable of synthesising and releasing insulin
What do the majority of genetic mutations in M.O.D.Y affect?
Glucokinase
Transcription Factors
Patients with M.O.D.Y have a lower resting blood glucose than people without diabetes. TRUE/FALSE?
FALSE
they have a HIGHER resting blood glucose
When do patients with Glucokinase mutations usually present?
Onset at birth
What is the difference between hyperglycaemia in Glucokinase and Transcription factor mutations?
Glucokinase mutations = stable hyperglycaemia through life
Transcription Factor mutations = progressive hyperglycaemia
How is a Glucokinase mutation M.O.D.Y treated?
Dietary measures
Are complications common or rare in glucokinase mutation M.O.D.Y?
Rare
When do Transcription Factor mutation M.O.D.Ys usually present?
Adolescence/young adult onset
How are Transcription factor mutation M.O.D.Ys treated?
1/3 diet
1/3 oral hypoglycaemic agents
1/3 Insulin
Are complications rare or common in Transcription factor mutation M.O.D.Y?
Common
When does neonatal diabetes usually occur?
3-6 months after birth
What are the two types of neonatal diabetes?
Transient (Resolves median 12 weeks - Stop insulin)
Permanent (Lifelong insulin)
Briefly explain how sulphonylureas work
close K-ATP channel
Membrane depolarised
Calcium influx
Insulin secretion
What is the main cause of neonatal diabetes?
Potassium (K-ATP) channel mutations
