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Flashcards in M.O.D.Y Deck (15)
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1

What does M.O.D.Y stand for?

Maturity onset diabetes of the young
=> Type 2-like Diabetes that comes on usually before the age of 25

2

If M.O.D.Y is similar to Type 2 diabetes, do patients require insulin?

No
They are still capable of synthesising and releasing insulin

3

What do the majority of genetic mutations in M.O.D.Y affect?

Glucokinase
Transcription Factors

4

Patients with M.O.D.Y have a lower resting blood glucose than people without diabetes. TRUE/FALSE?

FALSE
they have a HIGHER resting blood glucose

5

When do patients with Glucokinase mutations usually present?

Onset at birth

6

What is the difference between hyperglycaemia in Glucokinase and Transcription factor mutations?

Glucokinase mutations = stable hyperglycaemia through life

Transcription Factor mutations = progressive hyperglycaemia

7

How is a Glucokinase mutation M.O.D.Y treated?

Dietary measures

8

Are complications common or rare in glucokinase mutation M.O.D.Y?

Rare

9

When do Transcription Factor mutation M.O.D.Ys usually present?

Adolescence/young adult onset

10

How are Transcription factor mutation M.O.D.Ys treated?

1/3 diet
1/3 oral hypoglycaemic agents
1/3 Insulin

11

Are complications rare or common in Transcription factor mutation M.O.D.Y?

Common

12

When does neonatal diabetes usually occur?

3-6 months after birth

13

What are the two types of neonatal diabetes?

Transient (Resolves median 12 weeks - Stop insulin)

Permanent (Lifelong insulin)

14

Briefly explain how sulphonylureas work

close K-ATP channel
Membrane depolarised
Calcium influx
Insulin secretion

15

What is the main cause of neonatal diabetes?

Potassium (K-ATP) channel mutations