Type 2 Diabetes Drugs Flashcards Preview

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Flashcards in Type 2 Diabetes Drugs Deck (16)
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1

What are the main functions of Metformin?

↓Hepatic gluconeogenesis
↑peripheral glucose uptake

2

What are the advantages of using metformin in Type 2 Diabetes?

No hypoglycaemia when used as monotherapy
↓Cancer risk
↓CHD risk
Can be used in patients at any weight

3

What are the adverse effects of metformin?

GI upset (25% of people cant tolerate the drug)
Lactic acidosis

4

What value should Type 2 Diabetics aim to get their HbA1c levels under?

53mmol

5

What factors can increase the risk of failing to meet hyperglycaemic targets?

Younger
Female
Obese
Not at BP or Lipid targets
Complex glucose lowering therapies – 2 or 3 drugs

6

What are the main functions of sulphonylurea drugs?

Blocks beta cell KATP channel
=> Increase 1st and 2nd phase insulin secretion

7

What are the disasvantages of Sulphonylureas?

↑~2 Kg Weight gain
↑Hypoglycaemia
Abnormal LFTs

8

Above what dose does Gliclazide not make any further effect?

120mg

(normal dose is between 80-120mg)

9

How are GLP-1 agonists usually administered?

Via injection

10

Give examples of GLP-1 agonist drugs

Liraglutide (Victoza)
Dulaglutide (Trulicity)

11

Describe how the SGLT-2 drug class works

Prevents the usual 90% of glucose being reabsorbed
=> it is excreted in the urine

12

Give an example of the SGLT-2 drug class

Empagliflozin
Dampagliflozin

13

What is the main function of the glitazone drug class?

↑ peripheral glucose uptake

14

What adverse effects can be caused by the glitazone drug class?

↑3-5 Kg Weight gain
Fracture risk (x2-3)
Hepatotoxocity
Fluid retention

15

Why do the glitazone drug class cause an increased fracture risk?

they convert haematopoetic stem cells to adipose (fat) tissue in order for it to absorb more glucose

16

Give an example of a DPP-4 inhibitor

Sitagliptin