Flashcards in Type 2 Diabetes Drugs Deck (16)
What are the main functions of Metformin?
↑peripheral glucose uptake
What are the advantages of using metformin in Type 2 Diabetes?
No hypoglycaemia when used as monotherapy
Can be used in patients at any weight
What are the adverse effects of metformin?
GI upset (25% of people cant tolerate the drug)
What value should Type 2 Diabetics aim to get their HbA1c levels under?
What factors can increase the risk of failing to meet hyperglycaemic targets?
Not at BP or Lipid targets
Complex glucose lowering therapies – 2 or 3 drugs
What are the main functions of sulphonylurea drugs?
Blocks beta cell KATP channel
=> Increase 1st and 2nd phase insulin secretion
What are the disasvantages of Sulphonylureas?
↑~2 Kg Weight gain
Above what dose does Gliclazide not make any further effect?
(normal dose is between 80-120mg)
How are GLP-1 agonists usually administered?
Give examples of GLP-1 agonist drugs
Describe how the SGLT-2 drug class works
Prevents the usual 90% of glucose being reabsorbed
=> it is excreted in the urine
Give an example of the SGLT-2 drug class
What is the main function of the glitazone drug class?
↑ peripheral glucose uptake
What adverse effects can be caused by the glitazone drug class?
↑3-5 Kg Weight gain
Fracture risk (x2-3)
Why do the glitazone drug class cause an increased fracture risk?
they convert haematopoetic stem cells to adipose (fat) tissue in order for it to absorb more glucose