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Flashcards in Muscle Disease Deck (20):
1

What is the difference between polymyositis and dermatomyositis?

Dermatomyositis = polymyositis + skin changes

2

The risk of malignancy increases with polymyositis and dermatomyositis. True/False?

True

3

List the classic presenting MSK features of poly/dermato -myositis

Muscle weakness that worsens over months
Symmetrically affected
Myalgia
Difficulty with daily tasks

4

List investigations for poly/dermato -myositis

Inflammatory markers
Muscle enzyme (CK)
Autoantibodies
Electrolytes
Electromyography

5

Which antibodies are associated with poly/dermato -myositis?

ANA
Anti-Jo-1

6

What is the definitive test for poly/dermato -myositis?

Muscle biopsy

7

List the main treatment for poly/dermato -myositis

Steroids
Immunosuppression (methotrexate, azathioprine)
Ciclosporin
Rituximab

8

What is the steroid usually used for poly/dermato -myositis?

Prednisolone 40mg daily

9

Inclusion body myositis is more common in males. True/False?

True

10

Is muscle weakness in inclusion body myositis usually symmetrical or asymmetrical?

Asymmetrical

11

CK levels in inclusion body myositis are increased to a lesser fold compared to poly/dermato -myositis. True/False?

True

12

Inclusion body myositis is associated with anti-Jo-1 antibody. True/False?

False

13

Polymyalgia rheumatica is associated with which arteritic disease?

Giant cell arteritis

14

Muscle weakness if a feature of polymyalgia rheumatica. True/False?

False

15

List the common features of polymyalgia rheumatica

Morning stiffness - can't get out of bed
Fatigue
Anorexia
Reduced movement

16

What is the mainstay of treatment for polymyalgia rheumatica?

Low dose steroid - usually rapid/dramatic response

17

What is the commonest cause of chronic MSK pain?

Fibromyalgia

18

Is fibromyalgia inflammatory?

No

19

Fibromyalgia is commoner in which sex?

Women

20

List some clinical features of fibromyalgia

Broken sleep
Pain all over body
Pins and needles
Headaches
Depression
Tenderness on soft tissues