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Flashcards in Vasculitis Deck (33):
1

How does primary vasculitis arise?

Inflammatory response (can be autoimmune) that occurs in the walls of blood vessels, causing damage and reduced blood flow

2

List the 2 main large vessel vasculitis

Giant cell arteritis
Takayasu arteritis

3

List the 2 main medium vessel vasculitis

Polyarteritis nodosa
Kawasaki disease

4

Small vessel vasculitis can be generally divided into which 2 groups?

ANCA-associated
Non-ANCA-associated

5

Takayasu arteritis is commoner in males and in Asian populations. True/False?

False
Commoner in females and Asian populations

6

Giant cell arteritis affects those over 50 and is associated with which other disease?

Polymyalgia rheumatica

7

What is the most common finding in giant cell arteritis?

Carotid bruit

8

What is the mainstay of treatment for large vessel vasculitis?

Steroid (40-60mg prednisolone)

9

Which group of people is Kawasaki disease seen in?

Children

10

Which part of the artery is usually affected in polyarteritis nodosa?

Vessel bifurcations

11

Which hepatitis is associated with polyarteritis nodosa?

Hepatitis B

12

What are the old names for the ANCA-positive small vessel vasculitic diseases?

Wegener's granulomatosis
Churg-Strauss syndrome
Microscopic polyangitis

13

What are the new names for the ANCA-positive small vessel vasculitic diseases?

Granulomatosis with polyangitis (GPA)
Eosinophilic granulomatosis with polyangitis (EGPA)
Microscopic polyangitis (MPA)

14

Which of the 3 main ANCA-positive small vessel vasculitic diseases involve granulomatous inflammation?

GPA
EGPA

15

Which ANCA-positive small vessel vasculitic disease is associated with asthma?

EGPA

16

Which ANCA-positive small vessel vasculitic diseases are associated with glomerulonephritis?

GPA
MPA

17

GPA is more common in males. True/False?

True

18

When does GPA typically present?

35-55yrs old

19

What effect does GPA have on the nose?

Saddle nose due to cartilage ischaemia

20

What is the usual cutaneous manifestation of GPA?

Palpable purpura

21

What is mononeuritis multiplex and what effect can it have in GPA?

Impaired blood supply to nerve
Wrist/foot drop

22

What is the main difference between GPA and EGPA?

Late onset asthma
High eosinophil count

23

What are the 2 main types of ANCA?

pANCA
cANCA

24

Which vasculitis is associated with pANCA?

MPA
EGPA

25

Which vasculitis is associated with cANCA?

GPA

26

What is the antigen that pANCA primarily responds to in MPA?

MPO

27

What is the antigen that cANCA primarily responds to in GPA?

PR3

28

Outline treatment for localised/early systemic AAV

Methotrexate + steroid

29

Outline treatment for generalised/systemic AAV

Cyclophosphamide + steroid
Ritixumab + steroid
Azathioprine

30

Outline treatment for refractory AAV

IV immunoglobulins
Rituximab

31

What is the main non-ANCA-associated small vessel vasculitic disease?

Henoch-Schonlein Purpura (HSP)

32

Which Ig mediates HSP?

IgA

33

HSP is most common in which age range?

2-11 yrs old