How does primary vasculitis arise?
Inflammatory response (can be autoimmune) that occurs in the walls of blood vessels, causing damage and reduced blood flow
List the 2 main large vessel vasculitis
Giant cell arteritis
List the 2 main medium vessel vasculitis
Small vessel vasculitis can be generally divided into which 2 groups?
Takayasu arteritis is commoner in males and in Asian populations. True/False?
Commoner in females and Asian populations
Giant cell arteritis affects those over 50 and is associated with which other disease?
What is the most common finding in giant cell arteritis?
What is the mainstay of treatment for large vessel vasculitis?
Steroid (40-60mg prednisolone)
Which group of people is Kawasaki disease seen in?
Which part of the artery is usually affected in polyarteritis nodosa?
Which hepatitis is associated with polyarteritis nodosa?
What are the old names for the ANCA-positive small vessel vasculitic diseases?
What are the new names for the ANCA-positive small vessel vasculitic diseases?
Granulomatosis with polyangitis (GPA)
Eosinophilic granulomatosis with polyangitis (EGPA)
Microscopic polyangitis (MPA)
Which of the 3 main ANCA-positive small vessel vasculitic diseases involve granulomatous inflammation?
Which ANCA-positive small vessel vasculitic disease is associated with asthma?
Which ANCA-positive small vessel vasculitic diseases are associated with glomerulonephritis?
GPA is more common in males. True/False?
When does GPA typically present?
What effect does GPA have on the nose?
Saddle nose due to cartilage ischaemia
What is the usual cutaneous manifestation of GPA?
What is mononeuritis multiplex and what effect can it have in GPA?
Impaired blood supply to nerve
What is the main difference between GPA and EGPA?
Late onset asthma
High eosinophil count
What are the 2 main types of ANCA?
Which vasculitis is associated with pANCA?
Which vasculitis is associated with cANCA?
What is the antigen that pANCA primarily responds to in MPA?
What is the antigen that cANCA primarily responds to in GPA?
Outline treatment for localised/early systemic AAV
Methotrexate + steroid
Outline treatment for generalised/systemic AAV
Cyclophosphamide + steroid
Ritixumab + steroid
Outline treatment for refractory AAV
What is the main non-ANCA-associated small vessel vasculitic disease?
Henoch-Schonlein Purpura (HSP)
Which Ig mediates HSP?
HSP is most common in which age range?
2-11 yrs old