Rheum. Pharmacology Flashcards Preview

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Flashcards in Rheum. Pharmacology Deck (22):
1

Which drugs provide symptom relief in inflammatory arthritis?

Paracetamol
NSAIDs
Opiates
Atypical analgesics

2

Which two groups of drugs are classed as disease-modifying drugs in rheumatology?

DMARDs
Biologics

3

Give examples of DMARDS

Methotrexate
Sulphasalazine
Hydroxychloroquine

4

Give examples of biologics

Anti-TNF
Ritixumab

5

List some analgesic drugs

Co-codamol
Tramadol
Amitryptilline
Gabapentin

6

List some NSAIDs

Ibuprofen
Diclofenac
Celecoxib
Naproxen

7

DMARDs are fast-acting drugs. True/False?

False
Slow to act - weeks to months

8

What effect do DMARDs have?

Anti-inflammatory but NO DIRECT ANALGESIA
Reduce rate of joint damage

9

What is the "window of opportunity" for DMARDs and arthritic patients?

Start DMARD within 3 months of symptom onset

10

What are the 2 DMARDs of choice?

Methotrexate
Sulfasalazine

11

What is the supposed mode of action of methotrexate?

Folate antagonist

12

Methotrexate is teratogenic. What implication does this have?

Male and females must stop drug 3 months prior to conception of child

13

Does hydroxychloroquine have effect on joint damage?

No

14

What is the main anti-TNF drug?

Infliximab

15

Are anti-TNF drugs more effective than DMARDs?

Yes

16

What is the strict criteria for allowing use of anti-TNF?

Unresponsive to DMARDs
Scoring: count tender joints + rate activity of disease + check CRP

17

People on anti-TNF drugs must show response to allow continuation of the drug. True/False?

True

18

What drugs are given in acute gout?

Colchicine (diarrhoea, vomiting)
NSAID
Steroid

19

What is the main drug for gout treatment given following an acute attack?

Allopurinol

20

Which enzyme does allopurinol inhibit?

Xanthine oxidase to prevent uric acid production

21

Allopurinol should be prescribed in acute gout attack. True/False?

False
Can flareup acute gout

22

What is the alternative to allopurinol?

Febuxostat