Which drugs provide symptom relief in inflammatory arthritis?
Which two groups of drugs are classed as disease-modifying drugs in rheumatology?
Give examples of DMARDS
Give examples of biologics
List some analgesic drugs
List some NSAIDs
DMARDs are fast-acting drugs. True/False?
Slow to act - weeks to months
What effect do DMARDs have?
Anti-inflammatory but NO DIRECT ANALGESIA
Reduce rate of joint damage
What is the “window of opportunity” for DMARDs and arthritic patients?
Start DMARD within 3 months of symptom onset
What are the 2 DMARDs of choice?
What is the supposed mode of action of methotrexate?
Methotrexate is teratogenic. What implication does this have?
Male and females must stop drug 3 months prior to conception of child
Does hydroxychloroquine have effect on joint damage?
What is the main anti-TNF drug?
Are anti-TNF drugs more effective than DMARDs?
What is the strict criteria for allowing use of anti-TNF?
Unresponsive to DMARDs
Scoring: count tender joints + rate activity of disease + check CRP
People on anti-TNF drugs must show response to allow continuation of the drug. True/False?
What drugs are given in acute gout?
Colchicine (diarrhoea, vomiting)
What is the main drug for gout treatment given following an acute attack?
Which enzyme does allopurinol inhibit?
Xanthine oxidase to prevent uric acid production
Allopurinol should be prescribed in acute gout attack. True/False?
Can flareup acute gout
What is the alternative to allopurinol?