Flashcards in Connective Tissue Disease Deck (23):
Systemic lupus ertythematosus is a CTD. What is the general pathology behind connective tissue disease?
Autoimmunity; antibodies produced against cells of the body
SLE affects males more than females. True/False?
Females 9:1 males
Prevalence of SLE is higher in which ethnic groups?
List general symptoms + signs of SLE
List skin changes in SLE
N.B. sparing of nasolabial fold
SLE can be a totally cutaenous disease. True/False?
List musculoskeletal changes in SLE
What is the difference between mild, moderate and severe SLE?
Mild - 'simple' cutaneous changes
Mod - arthritis, effusions etc.
Sev - organ-threatening disease
What are the main screening tests for SLE?
What are the main antibodies that are raised in SLE?
ANA is the most useful/diagnostic antibody in SLE. True/False?
Anti-double-stranded DNA antibody is most specific
List general treatment for SLE
What is the anti-malarial used for SLE?
Steroids can be used as monotherapy in SLE. True/False?
What is antiphospholipid syndrome?
Autoimmune disease where antibodies are produced against phospholipid, causing increased risk of blood clots
One lab and one clinical finding are required to diagnose antiphospholipid syndrome. List the potential lab findings
+ve antiphospholipid antibody
Lupus anticoagulation activity
One lab and one clinical finding are required to diagnose antiphospholipid syndrome. List the potential clinical findings
What is Sjogren's syndrome?
Autoimmune destruction of exocrine glands
What is systemic sclerosis?
Autoimmune inflammation and thickening of skin due to increased collagen deposition
Raynaud's phenomenon is usually present in systemic sclerosis - what happens?
Reduced blood flow/vasculopathy
Limited systemic sclerosis was known as CREST - what does this stand for?
Which antibodies are associated with systemic sclerosis?