Connective Tissue Disease Flashcards Preview

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Flashcards in Connective Tissue Disease Deck (23):
1

Systemic lupus ertythematosus is a CTD. What is the general pathology behind connective tissue disease?

Autoimmunity; antibodies produced against cells of the body

2

SLE affects males more than females. True/False?

False
Females 9:1 males

3

Prevalence of SLE is higher in which ethnic groups?

Afro-Americans
Afro-Caribbeans
Asians

4

List general symptoms + signs of SLE

Fatigue
Skin changes
Malaise
Joint pain

5

List skin changes in SLE

Malar/butterfly/discoid rash
Photosensitivity
N.B. sparing of nasolabial fold

6

SLE can be a totally cutaenous disease. True/False?

True

7

List musculoskeletal changes in SLE

Joint pain
Non-deforming arthritis
Myopathy

8

What is the difference between mild, moderate and severe SLE?

Mild - 'simple' cutaneous changes
Mod - arthritis, effusions etc.
Sev - organ-threatening disease

9

What are the main screening tests for SLE?

FBC
Urinalysis
Renal function
Antibodies

10

What are the main antibodies that are raised in SLE?

ANA
Anti-ds-DNA
Anti-Sm
ENA

11

ANA is the most useful/diagnostic antibody in SLE. True/False?

False
Anti-double-stranded DNA antibody is most specific

12

List general treatment for SLE

NSAIDs, analgesia
Anti-malarial
Steroids
Immunosuppressants

13

What is the anti-malarial used for SLE?

Hydrochloroquine

14

Steroids can be used as monotherapy in SLE. True/False?

False

15

What is antiphospholipid syndrome?

Autoimmune disease where antibodies are produced against phospholipid, causing increased risk of blood clots

16

One lab and one clinical finding are required to diagnose antiphospholipid syndrome. List the potential lab findings

+ve antiphospholipid antibody
Lupus anticoagulation activity
anti-beta2-glycoprotein

17

One lab and one clinical finding are required to diagnose antiphospholipid syndrome. List the potential clinical findings

Thrombosis
Pregnancy loss

18

What is Sjogren's syndrome?

Autoimmune destruction of exocrine glands

19

What is systemic sclerosis?

Autoimmune inflammation and thickening of skin due to increased collagen deposition

20

Raynaud's phenomenon is usually present in systemic sclerosis - what happens?

Reduced blood flow/vasculopathy

21

Limited systemic sclerosis was known as CREST - what does this stand for?

Calconosis
Raynaud's
Esophageal dysmotility
Sclerodactyly
Telangectasia

22

Which antibodies are associated with systemic sclerosis?

Anti-centromere (limited)
Anti-Scl-70 (diffuse)

23

Which antibody is associated with Sjogren's syndrome?

Anti-Ro
Anti-La