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2MB Musculoskeletal > Immunology > Flashcards

Immunology Flashcards

1
Q

Which HLA allele is susceptible in ankylosing spondylitis?

A

HLA B27

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2
Q

Which HLA allele is susceptible in SLE?

A

HLA-DR3

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3
Q

Which type of hypersensitivity reaction is involved in SLE?

A

Type III

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4
Q

Which diseases is anti-centromere antibody associated with?

A

CREST/limited scleroderma

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5
Q

Which diseases is anti-Jo-1 antibody associated with?

A

Polymyositis
Dermatomyositis
Interstitial lung disease

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6
Q

Which disease is anti-La antibody associated with?

A

Sjogren’s syndrome

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7
Q

Which diseases is anti-ribonucleoprotein antibody associated with? (anti-RNP)

A

Mixed connective tissue disease

SLE

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8
Q

Which diseases is anti-Ro antibody associated with?

A

SLE

Sjogren’s syndrome

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9
Q

Which disease is anti-Smith antibody associated with?

A

SLE (very specific)

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10
Q

Rheumatoid arthritis is an example of which type of hypersensitivity?

A

Type IV

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11
Q

What are the 2 main potent stimulators of joint damage in rheumatoid arthritis?

A

TNF

IL-1

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2MB Musculoskeletal (19 decks)

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