Immunology

Question 1

Which HLA allele is susceptible in ankylosing spondylitis?

Answer 1

HLA B27

Question 2

Which HLA allele is susceptible in SLE?

Answer 2

HLA-DR3

Question 3

Which type of hypersensitivity reaction is involved in SLE?

Answer 3

Type III

Question 4

Which diseases is anti-centromere antibody associated with?

Answer 4

CREST/limited scleroderma

Question 5

Which diseases is anti-Jo-1 antibody associated with?

Answer 5

Polymyositis
Dermatomyositis
Interstitial lung disease

Question 6

Which disease is anti-La antibody associated with?

Answer 6

Sjogren’s syndrome

Question 7

Which diseases is anti-ribonucleoprotein antibody associated with? (anti-RNP)

Answer 7

Mixed connective tissue disease

SLE

Question 8

Which diseases is anti-Ro antibody associated with?

Answer 8

SLE

Sjogren’s syndrome

Question 9

Which disease is anti-Smith antibody associated with?

Answer 9

SLE (very specific)

Question 10

Rheumatoid arthritis is an example of which type of hypersensitivity?

Answer 10

Type IV

Question 11

What are the 2 main potent stimulators of joint damage in rheumatoid arthritis?

Answer 11

TNF

IL-1