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Flashcards in Immunology Deck (11)
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1
Q

Which HLA allele is susceptible in ankylosing spondylitis?

A

HLA B27

2
Q

Which HLA allele is susceptible in SLE?

A

HLA-DR3

3
Q

Which type of hypersensitivity reaction is involved in SLE?

A

Type III

4
Q

Which diseases is anti-centromere antibody associated with?

A

CREST/limited scleroderma

5
Q

Which diseases is anti-Jo-1 antibody associated with?

A

Polymyositis
Dermatomyositis
Interstitial lung disease

6
Q

Which disease is anti-La antibody associated with?

A

Sjogren’s syndrome

7
Q

Which diseases is anti-ribonucleoprotein antibody associated with? (anti-RNP)

A

Mixed connective tissue disease

SLE

8
Q

Which diseases is anti-Ro antibody associated with?

A

SLE

Sjogren’s syndrome

9
Q

Which disease is anti-Smith antibody associated with?

A

SLE (very specific)

10
Q

Rheumatoid arthritis is an example of which type of hypersensitivity?

A

Type IV

11
Q

What are the 2 main potent stimulators of joint damage in rheumatoid arthritis?

A

TNF

IL-1