Which HLA allele is susceptible in ankylosing spondylitis?
HLA B27
Which HLA allele is susceptible in SLE?
HLA-DR3
Which type of hypersensitivity reaction is involved in SLE?
Type III
Which diseases is anti-centromere antibody associated with?
CREST/limited scleroderma
Which diseases is anti-Jo-1 antibody associated with?
Polymyositis
Dermatomyositis
Interstitial lung disease
Which disease is anti-La antibody associated with?
Sjogren’s syndrome
Which diseases is anti-ribonucleoprotein antibody associated with? (anti-RNP)
Mixed connective tissue disease
SLE
Which diseases is anti-Ro antibody associated with?
SLE
Sjogren’s syndrome
Which disease is anti-Smith antibody associated with?
SLE (very specific)
Rheumatoid arthritis is an example of which type of hypersensitivity?
Type IV
What are the 2 main potent stimulators of joint damage in rheumatoid arthritis?
TNF
IL-1
