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Flashcards in Myeloma and Lymphoma Deck (37):
1

damaged light chains in urine called what?

Bence Jones protein

2

what is MGUS?

monocloncal gammopathy of Undetermined significance
"has the para protein but nothing else"

3

who gets MGUS?

more likely elderly

4

why is MGUS important?

more likely to transform to myeloma

5

does everyone with myeloma have hx of MGUS?

Nope

6

what do you see in marrow with multiple myeloma?

marrow full of plasma cells?

7

diagnostic criteria for myeloma?

M-protein in serum/urine
plasmacytoma
end-organ damage: CRAB

8

what is CRAB?

hypercalcaemia
renal insufficiency
anaemia
lytic bone lesions

9

what is beta-2 microglobulin?

measures plasma cell burden
but renal impairment alone can raise it

10

why is multiple myeloma called multiple?

affects multiple bones with lytic lesions 'pathological fracture', long bones, spinal

11

if patient is ill and has high total protein and low albumin, what could it be?

hidden protein (paraprotein)

12

what kind of lesions on x-ray for multiple myeloma?

lytic lesion

13

what is the best single agent for treating multiple myeloma?

melphalan

14

what is immune paresis?

in multiple myeloma, you have a high IgG kappa or lambda, but a very low lgA, IgM

15

transplant in myeloma is what?

autologous bone marrow, to allow recovery from the strong chemo

16

thalidomide use these days?

multiple myeloma

17

someone with paraprotein means myeloma?

Nope, probably MGUS, but watch out for CRAB features

18

lymphoma by definition is?

malignant

19

where can lymphoma arise?

liver
spleen
MALT
lymph nodes

20

2 most common hodgkin

NODULAE SCLEROSIS
MIXED CELLULARITY

21

classic hodgkin histology?

reid-sternberg cells
mixed infiltrate

22

B Cell Non hodgkin lymphoms high clinical aggressiveness is?

Burkitt Lymphoma

23

B Cell Non hodgkin lymphoma intermediate aggressiveness?

diffuse large B cell lymphoma

24

B Cell Non hodgkin lymphomas low aggressiveness?

follicular lymphoma

25

grade or stage in Non-hodgkin?

grade ('nastiness'"

26

what is stage?

WHERE it is.

27

non hodgkin lymphoma is grade of stage?

grade

28

Hodgkin lymphoma grade or stage more predictive?

stage

29

B symptoms?

weight loss
fever
night sweats

30

difference between non-hodgkins 1a and 1b stage?

1b has B-symptoms (do worse)

31

important cut off in hodgkin lymphoma treatment?

up to 2a (get radiotherapy only)
after 2b (radio and chemo)

32

what important biochem marker is elevated in non-hodgkin lymphoma?

LDH
lactate dehydrogenase

33

non hodgkin grade or stage?

grade

34

Burkitt lymphoma is what kind of lymphoma?

non hodgkin

35

what is CHOP?

Cyclophosphamide
Hydroxydornorubicin (Adriamycin)
Oncovin (vincristine)
Prednisolone

Rituximab

36

Rituximab targets what?

CD20 on B-cells

37

light chain restriction is what?

restricted to kappa or lambda light chains