Flashcards in Myeloma and Lymphoma Deck (37):
damaged light chains in urine called what?
Bence Jones protein
what is MGUS?
monocloncal gammopathy of Undetermined significance
"has the para protein but nothing else"
who gets MGUS?
more likely elderly
why is MGUS important?
more likely to transform to myeloma
does everyone with myeloma have hx of MGUS?
what do you see in marrow with multiple myeloma?
marrow full of plasma cells?
diagnostic criteria for myeloma?
M-protein in serum/urine
end-organ damage: CRAB
what is CRAB?
lytic bone lesions
what is beta-2 microglobulin?
measures plasma cell burden
but renal impairment alone can raise it
why is multiple myeloma called multiple?
affects multiple bones with lytic lesions 'pathological fracture', long bones, spinal
if patient is ill and has high total protein and low albumin, what could it be?
hidden protein (paraprotein)
what kind of lesions on x-ray for multiple myeloma?
what is the best single agent for treating multiple myeloma?
what is immune paresis?
in multiple myeloma, you have a high IgG kappa or lambda, but a very low lgA, IgM
transplant in myeloma is what?
autologous bone marrow, to allow recovery from the strong chemo
thalidomide use these days?
someone with paraprotein means myeloma?
Nope, probably MGUS, but watch out for CRAB features
lymphoma by definition is?
where can lymphoma arise?
2 most common hodgkin
classic hodgkin histology?
B Cell Non hodgkin lymphoms high clinical aggressiveness is?
B Cell Non hodgkin lymphoma intermediate aggressiveness?
diffuse large B cell lymphoma
B Cell Non hodgkin lymphomas low aggressiveness?
grade or stage in Non-hodgkin?
what is stage?
WHERE it is.
non hodgkin lymphoma is grade of stage?
Hodgkin lymphoma grade or stage more predictive?
difference between non-hodgkins 1a and 1b stage?
1b has B-symptoms (do worse)
important cut off in hodgkin lymphoma treatment?
up to 2a (get radiotherapy only)
after 2b (radio and chemo)
what important biochem marker is elevated in non-hodgkin lymphoma?
non hodgkin grade or stage?
Burkitt lymphoma is what kind of lymphoma?
what is CHOP?
Rituximab targets what?
CD20 on B-cells