Hapatobiliary Disease Flashcards Preview

Jason's MD2 ED/Amb Rotation > Hapatobiliary Disease > Flashcards

Flashcards in Hapatobiliary Disease Deck (17):
1

what changes you see first in liver failure? Albumin or INR?

INR first

Albumin takes weeks to change numbers

2

what does +ve ANA mean?

primary biliary cirrohosis

3

what 3 things are in the liver lobule unit?

bile duct
portal vein
hepatic artery

4

Chronic Hep B does what kind of damage to liver?

severe periportal activity

5

complications of viral hepatitis

cirrhosis
portal hypertension
liver failure
hepatocellular carcinoma (Hep B higher risk, don't need cirrhosis first)

6

cirrhosis defining features

bands of fibrosis that surround nodules
diffuse
distortion of architecture

7

Autoimmune Hepatitis: 3 kinds

Primary sclerosing cholangitis: large bile ducts
primary biliary cholangitis: small bile ducts

8

3 types of autoantibodies in autoimmune hepatitis?

Type 1: SMA, ANA (smooth muscle, Antinuclear ABs
Type 2: LKM1 (liver-kidney microsomal abs
Type 3: SLA (soluble liver Ag, liver/pancreas)

9

how to treat autoimmune hepatitis?

steroids: good response

10

Primary Biliary Cirrhosis pathology see what 2 things? how to treat?

granulomas
inflammatory small bile ducts

poor response to steroids
treat with ursodeoxycholic acid

11

which ducts does primary sclerosing cholangitis affect?

larger ducts

12

how to dx primary sclerosing cholangitis?

ERCP, MRCP

13

primary sclerosing cholangitis histology?

concentric fibrosis around a large bile duct, strictures, eventually disappears

14

who gets primary sclerosing cholangitis?

usu. crohn's or UC

15

paracetomol overdose histology damage where?

zone 3 necrosis

16

Alpha 1 anti-trypsin deficiency causes what clinically?

emphysema
cirrhosis

17

function of bile?

get rid of bilirubin
fat emulsification