Flashcards in Hapatobiliary Disease Deck (17)
what changes you see first in liver failure? Albumin or INR?
Albumin takes weeks to change numbers
what does +ve ANA mean?
primary biliary cirrohosis
what 3 things are in the liver lobule unit?
Chronic Hep B does what kind of damage to liver?
severe periportal activity
complications of viral hepatitis
hepatocellular carcinoma (Hep B higher risk, don't need cirrhosis first)
cirrhosis defining features
bands of fibrosis that surround nodules
distortion of architecture
Autoimmune Hepatitis: 3 kinds
Primary sclerosing cholangitis: large bile ducts
primary biliary cholangitis: small bile ducts
3 types of autoantibodies in autoimmune hepatitis?
Type 1: SMA, ANA (smooth muscle, Antinuclear ABs
Type 2: LKM1 (liver-kidney microsomal abs
Type 3: SLA (soluble liver Ag, liver/pancreas)
how to treat autoimmune hepatitis?
steroids: good response
Primary Biliary Cirrhosis pathology see what 2 things? how to treat?
inflammatory small bile ducts
poor response to steroids
treat with ursodeoxycholic acid
which ducts does primary sclerosing cholangitis affect?
how to dx primary sclerosing cholangitis?
primary sclerosing cholangitis histology?
concentric fibrosis around a large bile duct, strictures, eventually disappears
who gets primary sclerosing cholangitis?
usu. crohn's or UC
paracetomol overdose histology damage where?
zone 3 necrosis
Alpha 1 anti-trypsin deficiency causes what clinically?