Pathology - Thyroid Flashcards Preview

Jason's MD2 ED/Amb Rotation > Pathology - Thyroid > Flashcards

Flashcards in Pathology - Thyroid Deck (26):
1

2 benign thyroid nodules?

colloid nodule
follicular adenoma

2

why do FNA vs. core biopsy for thyroid?

lots of bleeding

3

what are some malignant causes of thyroid nodules?

papillary carcinoma
follicular carcinoma
medulary carcinoma
anaplastic carcinoma

4

multinodule goitre histo?

fibrosis
not well defined capsule
will get more colloid on FNA

5

follicular adenoma histology?

microfollicles
well defined thin capsule around it

6

FNA on follicular adenoma, will get more cells or colloid?

more cells

7

what is the most common malignant thyroid nodules?

papillary carcinoma (85%)

8

papillary carcinoma well defined capsule?

no

9

papillary carcinoma histo?

finger-like projections from the fibrous cores

10

papillary carcinoma histo architecture?

crowded enlarged nuclei "basket of eggs"

nuclear grooves

11

what histo is unique to papillary carcinoma

Psammomatous body - microcalcifications

12

follicular carcinoma vs. adenoma?

larger
thicker capsule
evidence of invasion

13

medullary carcinoma

C-cell derived (caltonin)
associated with MEN2
RET oncogene mutation
amyloid deposition

14

what kind of cancer arises from thyroid C-cells?

medullary carcinoma

15

what is the worst kind of tumour of thyroid?

anaplastic carcinoma

16

basic thyroid FNA principles?

more colloid: likely benign
more cells: likely be malignant

17

FNA can't differentiate?

follicular adenoma
follicular carcinoma

18

why total thyroidectomy for malignant thyroid?

papillary are multi-focal

19

category IV for follicular neoplasms are what cancers?

adenoma or carcinoma

20

malignant thyroid cytology in cells look like what?

coffee bean
nuclear pseudo-inclusions

21

most common thyroid cancer? (85%)

papillary thyroid carcinoma

22

who gets papillary thyroid carcinoma?

age 25-50

23

papillary thyroid carcinoma risk factor?

radiation exposure

24

papillary thyroid carcinoma one or more nodule presentation?

usu. one nodule

25

papillary thyroid carcinoma prognosis?

95% 10yr survival

26

Neck Lump differential

tumour
cyst
parathyroid
metastases
lymph node
salivary lesion