Glomerular Disease Flashcards Preview

Jason's MD2 ED/Amb Rotation > Glomerular Disease > Flashcards

Flashcards in Glomerular Disease Deck (27):
1

how much protein should be in urine normally?

2

how to test for protein in urine?

24 hour urine collection usually
spot protein-creatinine ratio
dipstick

3

how much RBCs should be in urine?

zero

4

blood in urine can look like 1 of 2 ways? where is it from?

dismorphic: glomerular
normal: non-glomerular

5

3 ways to looks at a renal biopsy?

light (H&E)
EM
Immunohistochem.immunofluoroscopy

6

glomeruli are affected in one of 4 ways geographically:

diffuse vs. focal (# of glomeruli in kidney as whole)

global vs segmental (of individual glomeruli)

7

5 symptoms of nephrotic syndrome?

proteinuria
oedema
decreased albumin
increase lipids
increased coagulation

8

4 symptoms of nephritic syndrome

haematuria
hypertension
incerased creatinine
oedema

9

2 main diseases what cause haematuria?

IgA nephropathy: most common
Post-infectious glomerulonephritis (immune complexes)

10

treatment for IgA nephropathy?

BP control

11

3 main conditions that cause proteinuria?

membranous
minimal change disease
focal segmental glomerulosclerosis

12

who gets membranous nephropathy? rule of 1/3s?

adults:
1/3 spontaneous recover
1/3 partial remit
1/3 progressive to ESKD

13

how to treat membranous nephropathy?

steroids, cyclophosphamide/cyclosporin

14

who gets minimal change disease? how to treat?

kids
treat with steroids

15

2 common causes of secondary focal segmental glomerulosclerosis?

HIV and obesity

16

what happens in focal segmental glomerulosclerosis??

progressive scarring of glomerulous to ESKD

17

who gets focal segmental glomerulosclerosis??

younger ppl in 20s

18

what condition has both proteinuria and haematuria?

membrano-proliferative

19

membrano-proliferative glomerulonephritis is linked to what diseases?

Hep B, C

20

3 systemic causes of glomerulonephritis?

Lupus
Diabetes
Amyloidosis

21

2 important not to be missed rapidly progressive glomerulonephritises?

Wegner's
Goodpasture's

22

3 classes of rapidly progressive glomerulonephritises?

ANCA
Anti-Glomerular Basement Membrane disease (collagen type 4)
Immune complexes

23

Wegner's is what ANCA?

cANCA (cytoplasmic)

24

Goodpasture's affects what?

kidneys and lungs with anti-basement membrane antbodies

25

what disease of rapidly progressive glomerulonephritises caused by immune complexes?

lupus

26

important side effects of cyclophosphamide?

infertility
infections
TCC
nausea
hair loss

27

4 things that glomerulonephritis associated with?

proteinuria
haematuria
hypertension
impaired renal function (increase creatinine)